Sushil Kumar
University of Montana
45 Papers
161 Citations
Sushil Kumar is an academic researcher from University of Montana. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 14, co-authored 31 publications. Previous affiliations of Sushil Kumar include University of North Texas Health Science Center & University of Colorado Denver.
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Papers
Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis
Hui Zhang,Daren Wang,Min Li,Lydie Plecitá-Hlavatá,Angelo D'Alessandro,Jan Tauber,Suzette R. Riddle,Sushil Kumar,Amanda Flockton,B. Alexandre McKeon,Maria G. Frid,Julie A. Reisz,Paola Caruso,Karim C. El Kasmi,Petr Ježek,Nicholas W. Morrell,Cheng-Jun Hu,Kurt R. Stenmark +17 more
TL;DR: In PH, miR-124 regulates the PKM2/PKM1 ratio, the overall metabolic, proliferative, and inflammatory state of cells, which may open unique therapeutic prospects in targeting the dynamic glycolytic and mitochondrial interactions and between mesenchymal inflammatory cells in PH.
207
Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1.
Min Li,Suzette R. Riddle,Hui Zhang,Angelo D'Alessandro,Amanda Flockton,Natalie J. Serkova,Kirk C. Hansen,Radu Moldovan,B. Alexandre McKeon,Maria G. Frid,Sushil Kumar,Hong Li,Hongbing Liu,Angela Caánovas,Juan F. Medrano,Milton G Thomas,Dijana Iloska,Lydie Plecitá-Hlavatá,Petr Ježek,Soni Savai Pullamsetti,Mehdi A. Fini,Karim C. El Kasmi,Qinghong Zhang,Kurt R. Stenmark +23 more
TL;DR: In this article, changes in metabolism have been suggested to contribute to the aberrant phenotype of vascular wall cells, including fibroblasts, in pulmonary hypertension (PH) patients.
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Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension
Maria G. Frid,B. Alexandre McKeon,Joshua M. Thurman,Bradley A. Maron,Min Li,Hui Zhang,Sushil Kumar,Timothy M. Sullivan,Jennifer Laskowsky,Mehdi A. Fini,Samantha Hu,Rubin M. Tuder,Aneta Gandjeva,Martin R. Wilkins,Christopher J. Rhodes,Pavandeep Ghataorhe,Jane A. Leopold,Rui-Sheng Wang,V. Michael Holers,Kurt R. Stenmark +19 more
TL;DR: This study establishes immunoglobulin-driven dysregulated complement activation as acritical pathobiological mechanism regulating proinflammatory and pro-proliferative processes in the initiation of experimental hypoxic PH and demonstrates complement signaling as a critical determinant of clinical outcome in PAH.
91
Detecting aerobic bacterial diversity in patients with diabetic foot wounds using ERIC-PCR: a preliminary communication.
Surya Kumar Singh,K B Gupta,S. K. Tiwari,Shailesh K. Shahi,Sushil Kumar,Ashok Kumar,Sanjeev K. Gupta +6 more
TL;DR: The bacterial diversity in diabetic foot infections at genetic level is found by finger printing, that is, ERIC-PCR (enterobacterial repetitive intergenic consensus -polymerase chain reaction) using standard microbiological culture methods.
43
Silibinin and colorectal cancer chemoprevention: a comprehensive review on mechanisms and efficacy.
TL;DR: The ultimate goal of this approach is to reduce the incidence of pre-neoplastic adenomatous polyps and prevent their progression to more advanced forms of CRC, and use these natural agents as a safe intervention strategy during the clinical course of this deadly malignancy.
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