Susanne Clausmeyer
Heidelberg University
7 Papers
196 Citations
Susanne Clausmeyer is an academic researcher from Heidelberg University. The author has contributed to research in topics: Zona glomerulosa & Renin–angiotensin system. The author has an hindex of 7, co-authored 7 publications.
Chat about Author
Papers
An Alternative Transcript of the Rat Renin Gene Can Result in a Truncated Prorenin That Is Transported Into Adrenal Mitochondria
TL;DR: To investigate the transport of renin into mitochondria, a series of amino-terminal deletion variants of preprorenin were constructed and one of these variants, lacking the complete signal sequence for the endoplasmic reticulum and 10 amino acids of the profragment, was transported efficiently into isolated mitochondria.
117
Intracellular sorting of renin: cell type specific differences and their consequences.
Jörg Peters,Susanne Clausmeyer +1 more
TL;DR: Exon1A renin transcript levels, in contrast, markedly increased after myocardial ischemia, provides a new molecular basis for a function of locally expressed renin, which is apparently of functional significance.
52
Cytosolic renin is targeted to mitochondria and inducesapoptosis in H9c2 rat cardiomyoblasts
Heike Wanka,Nicole Keßler,Janett Ellmer,Nicole Endlich,Barbara S. Peters,Susanne Clausmeyer,Jörg Peters +6 more
TL;DR: The data demonstrate that a cytosolic renin exists in cardiomyocytes, which in contradiction to secretory renin protects from necrosis but increases apoptosis, which can be considered as a new target for cardiac failure.
Specific regulation of StAR expression in the rat adrenal zona glomerulosa. An in situ hybridization study.
Barbara Peters,Susanne Clausmeyer,Nicholas Obermüller,Alexander Woyth,Bettina Kränzlin,Norbert Gretz,Jörg Peters +6 more
TL;DR: It is demonstrated that the width of the aldosterone-producing zone can increase within a short period of time by recruiting hormonally inactive cells to steroidogenesis, and the outermost five to seven parenchymal cell layers express the StAR gene only weakly and inhomogeneously.
31
StAR expression and the long-term aldosterone response to high-potassium diet in Wistar-Kyoto and spontaneously hypertensive rats
Barbara S. Peters,Philipp Teubner,Susanne Clausmeyer,Tanja Puschner,Christiane Maser-Gluth,Hans-Josef Wrede,Bettina Kränzlin,Jörg Peters +7 more
TL;DR: An increase of StAR mRNA levels within the outer cortex is involved in the long-term adrenal response to potassium, and this increase alone is not sufficient to increase aldosterone production in the presence of normal Cyp11b2 mRNA levels.
19