Susan Marquez
Wyss Institute for Biologically Inspired Engineering
7 Papers
Susan Marquez is an academic researcher from Wyss Institute for Biologically Inspired Engineering. The author has contributed to research in topics: Bone marrow & Medicine. The author has an hindex of 4, co-authored 5 publications.
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Papers
Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips.
Anna Herland,Anna Herland,Anna Herland,Ben M. Maoz,Debarun Das,Mahadevabharath R. Somayaji,Rachelle Prantil-Baun,Richard M. Novak,Michael J. Cronce,Tessa Huffstater,Sauveur S. F. Jeanty,Miles Ingram,Angeliki Chalkiadaki,David B. Chou,Susan Marquez,Aaron Delahanty,Sasan Jalili-Firoozinezhad,Sasan Jalili-Firoozinezhad,Yuka Milton,Alexandra Sontheimer-Phelps,Alexandra Sontheimer-Phelps,Ben Swenor,Oren Levy,Kevin Kit Parker,Kevin Kit Parker,Andrzej Przekwas,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +28 more
TL;DR: Physiological modelling of first-pass metabolism using data from a robotic instrument that fluidically links relevant organ chips predicts human pharmacokinetic parameters for orally administered nicotine and for intravenously injected cisplatin.
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Robotic fluidic coupling and interrogation of multiple vascularized organ chips.
Richard M. Novak,Miles Ingram,Susan Marquez,Debarun Das,Aaron Delahanty,Anna Herland,Anna Herland,Ben M. Maoz,Ben M. Maoz,Ben M. Maoz,Sauveur S. F. Jeanty,Mahadevabharath R. Somayaji,Morgan Burt,Elizabeth Calamari,Angeliki Chalkiadaki,Alexander Cho,Youngjae Choe,David B. Chou,David B. Chou,Michael J. Cronce,Stephanie Dauth,Stephanie Dauth,Toni Divic,Jose Fernandez-Alcon,Thomas C. Ferrante,John P. Ferrier,John P. Ferrier,Edward A. FitzGerald,Rachel Fleming,Sasan Jalili-Firoozinezhad,Sasan Jalili-Firoozinezhad,Thomas Grevesse,Thomas Grevesse,Josue A. Goss,Josue A. Goss,Tiama Hamkins-Indik,Olivier Y.F. Henry,Chris Hinojosa,Tessa Huffstater,Kyung-Jin Jang,Ville J. Kujala,Ville J. Kujala,Lian Leng,Robert Mannix,Robert Mannix,Yuka Milton,Janna Nawroth,Janna Nawroth,Bret Nestor,Carlos F. Ng,Blakely B. O'Connor,Blakely B. O'Connor,Tae-Eun Park,Henry Sanchez,Josiah Sliz,Alexandra Sontheimer-Phelps,Alexandra Sontheimer-Phelps,Ben Swenor,Guy Robert Thompson,George J. Touloumes,George J. Touloumes,Zachary Tranchemontagne,Norman Wen,Moran Yadid,Moran Yadid,Anthony Bahinski,Anthony Bahinski,Geraldine A. Hamilton,Daniel Levner,Oren Levy,Andrzej Przekwas,Rachelle Prantil-Baun,Kevin Kit Parker,Kevin Kit Parker,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +76 more
TL;DR: An 'interrogator' that employs liquid-handling robotics, custom software and an integrated mobile microscope for the automated culture, perfusion, medium addition, fluidic linking, sample collection and in situ microscopy imaging of up to ten organ chips inside a standard tissue-culture incubator is described.
On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology.
David B. Chou,David B. Chou,Viktoras Frismantas,Yuka Milton,Rhiannon David,Petar Pop-Damkov,Douglas Ferguson,Alexander MacDonald,Özge Vargel Bölükbaşı,Cailin E. Joyce,Liliana Moreira Teixeira,Arianna Rech,Arianna Rech,Amanda Jiang,Elizabeth Calamari,Sasan Jalili-Firoozinezhad,Sasan Jalili-Firoozinezhad,Brooke A. Furlong,Lucy R. O’Sullivan,Carlos F. Ng,Youngjae Choe,Susan Marquez,Kasiani C. Myers,Kasiani C. Myers,Olga K. Weinberg,Robert P. Hasserjian,Richard M. Novak,Oren Levy,Rachelle Prantil-Baun,Carl D. Novina,Carl D. Novina,Akiko Shimamura,Lorna Ewart,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +35 more
TL;DR: A vascularized human bone-marrow-on-a-chip improves the maintenance of patient-derived CD34 + cells, and recapitulates clinically relevant aspects of bone marrow injury as well as key haematopoietic defects of patients with a rare genetic disorder.
Author Correction: On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology
David B. Chou,Viktoras Frismantas,Yuka Milton,Rhiannon David,Petar Pop-Damkov,Douglas Ferguson,Alexander MacDonald,Özge Vargel Bölükbaşı,Cailin E. Joyce,Liliana Moreira Teixeira,Arianna Rech,Arianna Rech,Amanda Jiang,Elizabeth Calamari,Sasan Jalili-Firoozinezhad,Sasan Jalili-Firoozinezhad,Brooke A. Furlong,Lucy R. O’Sullivan,Carlos F. Ng,Youngjae Choe,Susan Marquez,Kasiani C. Myers,Kasiani C. Myers,Olga K. Weinberg,Robert P. Hasserjian,Richard M. Novak,Oren Levy,Rachelle Prantil-Baun,Carl D. Novina,Carl D. Novina,Akiko Shimamura,Lorna Ewart,Donald E. Ingber +32 more
TL;DR: An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Identification of a pharmaceutical biostasis inducer that slows metabolism in multiple vertebrates that do not hibernate
Megan M. Sperry,Bérénice Charrez,Haleh Fotowat,Erica Gardner,Kanoelani T. Pilobello,Zohreh Izadifar,Tiffany Lin,Abigail Kuelker,Sahith Kaki,Michael Lewandowski,Shanda L. Lightbown,Ramses Martinez,Susan Marquez,Adama M. Sesay,K. Shcherbina,Takako Takeda,Kristina Andrijauskaite,Exal Cisneros,R. Lopez,Isabella Cano,Zachary Maxwell,Rafael Veraza,Leonid Bunegin,Thomas J. Percival,Jaclyn L Yracheta,Jorge Pena,Diandra Wood,Zachary Homas,Cody Hinshaw,Jen Cox-Hinshaw,O. Parry,Justin J. Sleeter,Erik K. Weitzel,M. Vazquez Levin,Michael Super,Richard Novák,Donald E. Ingber +36 more
TL;DR: In this paper , an injectable biostasis drug that could slow organ injury by inducing a state of suspended animation through reversible slowing of metabolic processes would have great value for organ preservation and treatment of badly injured patients at the point of care.