Susan M. Domchek
University of Pennsylvania
535 Papers
2.1K Citations
Susan M. Domchek is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 83, co-authored 439 publications. Previous affiliations of Susan M. Domchek include Brigham and Women's Hospital & Cancer Council Victoria.
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Papers
A phase II open-label, multicenter study of single-agent rucaparib in the treatment of patients with relapsed ovarian cancer and a deleterious BRCA mutation.
Ronnie Shapira-Frommer,Amit M. Oza,Susan M. Domchek,Judith Balmaña,Manish R. Patel,Lee-may Chen,Yvette Drew,Howard A. Burris,Jacob Korach,Michael Flynn,Valerie Bowering,Mark A. Morgan,Simon Paul Watkins,Dayna Simpson,Sandra Goble,Lara Maloney,Rebecca Kristeleit +16 more
TL;DR: This phase II study evaluated the efficacy and safety of rucaparib in pts with relapsed gBRCAmut high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer and the primary endpoint was objective response rate (ORR) by RECIST 1.1.
CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients
Andrew J. Rech,Rosemarie Mick,Sunil Martin,Adri Recio,Nicole A. Aqui,Daniel J. Powell,Theresa A. Colligon,Jennifer A. Trosko,L. Leinbach,Charles H. Pletcher,Carol Kaplan Tweed,Angela DeMichele,Kevin Fox,Susan M. Domchek,James L. Riley,Robert H. Vonderheide +15 more
TL;DR: It is concluded that CD25 blockade depletes and selectively reprograms Tregs in concert with active immune therapy in cancer patients, suggesting a mechanism to target cancer-associated T Regs while avoiding autoimmunity.
Olaparib versus chemotherapy treatment of physician’s choice in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer (OlympiAD): Efficacy in patients with visceral metastases.
Nadine Tung,Seock-Ah Im,Elżbieta Senkus-Konefka,Binghe Xu,Susan M. Domchek,Norikazu Masuda,Wei Li,Anne C Armstrong,Pierfranco Conte,W. Wu,C. Goessl,Sarah Runswick,Mark E. Robson +12 more
TL;DR: The OlympiAD study showed a significant progression-free survival benefit for olaparib over chemotherapy treatment of physician’s choice (TPC) in patients with HER2-negative m...
Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography
Brad M. Keller,Anne Marie McCarthy,Jinbo Chen,Katrina Armstrong,Emily F. Conant,Susan M. Domchek,Despina Kontos +6 more
TL;DR: The majority of SNPs investigated in this study were not found to be significantly associated with breast density, even when accounting for age, BMI, and Gail risk, suggesting that these two different risk factors contain potentially independent information regarding a woman's risk to develop breast cancer.
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus
Chenjie Zeng,Xingyi Guo,Jirong Long,Karoline Kuchenbaecker,Arnaud Droit,Kyriaki Michailidou,Maya Ghoussaini,Siddhartha Kar,Adam N. Freeman,John L. Hopper,Roger L. Milne,Roger L. Milne,Manjeet K. Bolla,Qin Wang,Joe Dennis,Simona Agata,Shahana Ahmed,Kristiina Aittomäki,Irene L. Andrulis,Hoda Anton-Culver,Natalia Antonenkova,Adalgeir Arason,Volker Arndt,Banu Arun,Brita Arver,Francois Bacot,Daniel Barrowdale,Caroline Baynes,Alicia Beeghly-Fadiel,Javier Benitez,Marina Bermisheva,Carl Blomqvist,William J. Blot,Natalia Bogdanova,Stig E. Bojesen,Bernardo Bonanni,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Judith S. Brand,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Paul Brennan,Hermann Brenner,Annegien Broeks,Thomas Brüning,Barbara Burwinkel,Barbara Burwinkel,Saundra S. Buys,Qiuyin Cai,Trinidad Caldés,Ian G. Campbell,Jane Carpenter,Jenny Chang-Claude,Jenny Chang-Claude,Ji Yeob Choi,Ji Yeob Choi,Kathleen Claes,Christine L. Clarke,Angela Cox,Simon S. Cross,Kamila Czene,Mary B. Daly,Miguel de la Hoya,Kim De Leeneer,Peter Devilee,Orland Diez,Susan M. Domchek,Michele M. Doody,Cecilia M. Dorfling,Thilo Dörk,Isabel dos-Santos-Silva,Martine Dumont,Miriam Dwek,Bernd Dworniczak,Kathleen M. Egan,Ursula Eilber,Zakaria Einbeigi,Bent Ejlertsen,Steve Ellis,Debra Frost,Fiona Lalloo,Peter A. Fasching,Peter A. Fasching,Jonine Figueroa,Henrik Flyger,Michael Friedlander,Eitan Friedman,Gaetana Gambino,Yu-Tang Gao,Judy Garber,Montserrat Garcia-Closas,Andrea Gehrig,Francesca Damiola,Fabienne Lesueur,Sylvie Mazoyer,Dominique Stoppa-Lyonnet,Dominique Stoppa-Lyonnet,Graham G. Giles,Graham G. Giles,Andrew K. Godwin,David E. Goldgar,Anna González-Neira,Mark H. Greene,Pascal Guénel,Lothar Haeberle,Christopher A. Haiman,Emily Hallberg,Ute Hamann,Thomas Hansen,Steven N. Hart,Jaana M. Hartikainen,Mikael Hartman,Mikael Hartman,Norhashimah Hassan,Sue Healey,Frans B. L. Hogervorst,Senno Verhoef,Carolyn B. Hendricks,Carolyn B. Hendricks,Peter Hillemanns,Antoinette Hollestelle,Peter J. Hulick,David J. Hunter,Evgeny N. Imyanitov,Claudine Isaacs,Hidemi Ito,Anna Jakubowska,Ramunas Janavicius,Katarzyna Jaworska-Bieniek,Uffe Birk Jensen,Esther M. John,Esther M. John,Charles Joly Beauparlant,Michael Jones,Maria Kabisch,Daehee Kang,Daehee Kang,Beth Y. Karlan,Saila Kauppila,Michael J. Kerin,Sofia Khan,Elza Khusnutdinova,Elza Khusnutdinova,Julia A. Knight,Irene Konstantopoulou,Peter Kraft,Ava Kwong,Yael Laitman,Diether Lambrechts,Conxi Lázaro,Loic Le Marchand,Chuen Neng Lee,Min Hyuk Lee,Jenny Lester,Jingmei Li,Annelie Liljegren,Annika Lindblom,Artitaya Lophatananon,Jan Lubinski,Phuong L. Mai,Arto Mannermaa,Siranoush Manoukian,Sara Margolin,Frederik Marmé,Keitaro Matsuo,Lesley McGuffog,Alfons Meindl,Florence Menegaux,Marco Montagna,Kenneth Muir,Kenneth Muir,Anna Marie Mulligan,Katherine L. Nathanson,Susan L. Neuhausen,Heli Nevanlinna,Polly A. Newcomb,Polly A. Newcomb,Silje Nord,Robert L. Nussbaum,Kenneth Offit,Edith Olah,Olufunmilayo I. Olopade,Curtis Olswold,Ana Osorio,Laura Papi,Tjoung Won Park-Simon,Ylva Paulsson-Karlsson,Stéphanie Peeters,Bernard Peissel,Paolo Peterlongo,Julian Peto,Georg Pfeiler,Catherine M. Phelan,Nadege Presneau,Paolo Radice,Nazneen Rahman,Susan J. Ramus,Muhammad Usman Rashid,Gad Rennert,Kerstin Rhiem,Anja Rudolph,Ritu Salani,Suleeporn Sangrajrang,Elinor J. Sawyer,Marjanka K. Schmidt,Rita K. Schmutzler,Minouk J. Schoemaker,Peter Schürmann,Caroline Seynaeve,Chen-Yang Shen,Chen-Yang Shen,Martha J. Shrubsole,Xiao-Ou Shu,Alice J. Sigurdson,Christian F. Singer,Susan L. Slager,Penny Soucy,Melissa C. Southey,Doris Steinemann,Anthony J. Swerdlow,Csilla Szabo,Sandrine Tchatchou,Manuel R. Teixeira,Soo Hwang Teo,Mary Beth Terry,Daniel C. Tessier,Alex Teulé,Mads Thomassen,Laima Tihomirova,Marc Tischkowitz,Marc Tischkowitz,Amanda E. Toland,Nadine Tung,Clare Turnbull,Ans M.W. van den Ouweland,Elizabeth J. van Rensburg,David ven den Berg,Joseph Vijai,Shan Wang-Gohrke,Jeffrey N. Weitzel,Alice S. Whittemore,Robert Winqvist,Tien Yin Wong,Anna H. Wu,Drakoulis Yannoukakos,Jyh Cherng Yu,Paul D.P. Pharoah,Per Hall,Georgia Chenevix-Trench,Georgia Chenevix-Trench,Alison M. Dunning,Jacques Simard,Fergus J. Couch,Antonis C. Antoniou,Douglas F. Easton,Wei Zheng +256 more
TL;DR: This study identified four independent association signals at 12 p11 and revealed potentially functional variants, providing additional insights into the underlying biological mechanism(s) for the association observed between variants at 12p11 and breast cancer risk.