Susan M. Domchek
University of Pennsylvania
535 Papers
2.1K Citations
Susan M. Domchek is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 83, co-authored 439 publications. Previous affiliations of Susan M. Domchek include Brigham and Women's Hospital & Cancer Council Victoria.
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Papers
Abstract 4511: Characterization of tumor neoantigen repertoire in patients with germline BRCA1/2 mutations
Adam A. Kraya,Kara N. Maxwell,Brandon Wenz,Bradley Wubbenhorst,Daniel DeSloover,Nicole Lunceford,Jennifer J.D. Morrissette,Michael Feldman,Robert H. Vonderheide,Susan M. Domchek,Katherine L. Nathanson +10 more
TL;DR: The neoantigen repertoire in 20 breast and 19 ovarian tumors from patients with germline BRCA1/2 mutations is characterized, with positive correlates of neoantigens load in the authors' studies included mutational burden.
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Patterns and predictors of BRCA 1/2 testing in young breast cancer survivors.
Shoshana M. Rosenberg,Kathryn J. Ruddy,William T. Barry,Kim Sprunck,Jennifer A. Ligibel,Susan M. Domchek,Ann H. Partridge +6 more
TL;DR: The Young and Strong Study evaluated an education and support intervention for women, aged 18-45, diagnosed in 2012-2013, with early stage BC, and used logistic regression to identify predictors of not undergoing testing.
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Abstract P6-07-05: Mutational spectrum and tumor response in metastatic breast cancer
Danielle Soucier-Ernst,Christopher Colameco,Andrea B. Troxel,Carolyn E. Clark,N Shih,Kara N. Maxwell,J. Morrissette,David B. Lieberman,Michael Feldman,Noah Goodman,Angela R. Bradbury,Amy S. Clark,Susan M. Domchek,Kevin Fox,John H. Glick,Jennifer M. Matro,K. L. Nathanson,Lewis A. Chodosh,AM DeMichele +18 more
TL;DR: While overall # of muts did not affect response, tumors with TP53 muts had shorter response to subsequent therapy in this cohort, and additional data are needed to determine the clinical utility of mut testing in met BC.
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Abstract LB-425: Replication of 18 susceptibility loci of breast cancer in women of African ancestry
Dezheng Huo,Yonglan Zheng,Temidayo O. Ogundiran,Clement Adebamowo,Katherine L. Nathanson,Susan M. Domchek,Timothy R. Rebbeck,Esther M. John,Anselm Hennis,Barbara Nemesure,Suh-Yuh Wu,Stefan Ambs,Qun Niu,Jing Zhang,Nancy J. Cox,Olufunmilayo I. Olopade +15 more
TL;DR: This study highlights the complexity of applying current GWAS findings across racial/ethnic groups, as none of GWAS-identified index SNPs could be replicated in women of African ancestry, but two SNPs identified from previous fine-mapping studies were significantly associated with breast cancer risk in the present study.
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