Susan Lapthorne
Cork University Hospital
13 Papers
49 Citations
Susan Lapthorne is an academic researcher from Cork University Hospital. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 7, co-authored 13 publications. Previous affiliations of Susan Lapthorne include University College Cork & National University of Ireland.
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Papers
Involvement of T helper type 17 and regulatory T cell activity in Citrobacter rodentium invasion and inflammatory damage.
Erin L. Symonds,Christian U. Riedel,Denis O'Mahony,Susan Lapthorne,Liam O'Mahony,Fergus Shanahan +5 more
TL;DR: There were significant immunological changes, with up‐regulation of the Th17 and Treg pathways in the distal colon and an increase in ghrelin expression compared with non‐infected control mice, which may play a role in the pathology and clearance of C. rodentium.
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Bifidobacterium infantis 35624 protects against salmonella-induced reductions in digestive enzyme activity in mice by attenuation of the host inflammatory response.
Erin L. Symonds,Caitlin O'Mahony,Susan Lapthorne,David O'Mahony,John Mac Sharry,Liam O'Mahony,Liam O'Mahony,Fergus Shanahan +7 more
TL;DR: Salmonella infection reduces the small intestinal brush border enzyme activity in mice, with the level of reduction and associated weight loss increasing with dose and duration of infection.
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Differential intestinal M-cell gene expression response to gut commensals.
TL;DR: It is demonstrated that M cells have the ability to discriminate between different commensal bacteria and modify subsequent immune responses and Translocation of bacteria and M‐cell gene expression responses were confirmed in murine M cells following bacterial challenge in vivo.
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Concomitant Exposure to Ovalbumin and Endotoxin Augments Airway Inflammation but Not Airway Hyperresponsiveness in a Murine Model of Asthma
John Mac Sharry,Karim H. Shalaby,Cinzia L. Marchica,Soroor Farahnak,Tien Chieh-Li,Susan Lapthorne,Salman T. Qureshi,Fergus Shanahan,James G. Martin +8 more
TL;DR: Contaminating LPS is not required for induction of airway hyperresponsiveness but amplifies the Th2 inflammatory response and is a critical mediator of the neutrophil, Th1 and T regulatory cell responses to OVA.
Long Term Disruption of Cytokine Signalling Networks are Evident in Patients that Required Hospitalisation for SARS-CoV-2 Infection.
Sinead Ahearn-Ford,Nonhlanhla Lunjani,Brian P. McSharry,John MacSharry,Liam J. Fanning,Gerard Murphy,Cormac Everard,Aoife Barry,Aimee McGreal,Sultan Mohamed al Lawati,Susan Lapthorne,Colin Sherlock,Anna McKeogh,Arthur Jackson,Eamonn Faller,Mary Horgan,Mary Horgan,Corinna Sadlier,Liam O'Mahony +18 more
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