Susan Hicks
Royal Free Hospital
18 Papers
149 Citations
Susan Hicks is an academic researcher from Royal Free Hospital. The author has contributed to research in topics: Intestinal mucosa & Enteroaggregative Escherichia coli. The author has an hindex of 12, co-authored 17 publications. Previous affiliations of Susan Hicks include University of Maryland, Baltimore.
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Papers
A novel dispersin protein in enteroaggregative Escherichia coli
Jalaluddin Sheikh,John R. Czeczulin,Susan M. Harrington,Susan Hicks,Ian R. Henderson,Chantal Le Bouguénec,Pierre Gounon,Alan D. Phillips,James P. Nataro +8 more
TL;DR: It is proposed that the aap gene product participates in formation of a surface coat that acts to disperse the bacteria, thus partially counteracting aggregation mediated by aggregative adherence fimbriae and holding considerable promise as an EAEC immunogen.
Enterohaemorrhagic Escherichia coli O157:H7 target Peyer's patches in humans and cause attaching/effacing lesions in both human and bovine intestine.
TL;DR: O157:H7 targets follicle associated epithelium in humans where it causes attaching/effacing lesions in humans, indicating that similar pathogenic mechanisms operate across human and bovine species.
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Role of Intimin and Bundle-Forming Pili in Enteropathogenic Escherichia coli Adhesion to Pediatric Intestinal Tissue In Vitro
TL;DR: In human intestinal organ culture, BFP do not appear to be involved in the initial stages of EPEC nonintimate adhesion but are implicated in the formation of complex, three-dimensional colonies via bacterium-bacterium interactions.
206
Generation of Escherichia coli intimin derivatives with differing biological activities using site‐directed mutagenesis of the intimin C‐terminus domain
TL;DR: It is reported that intimin‐mediated A/E lesion formation can be segregated from intimin-mediated HEp‐2 cell invasion and adherence to IVOC, EPEC‐induced microvillus elongation and colonization of the murine intestine by C. rodentium were also modulated by the modified intimins.
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Intimin from enteropathogenic Escherichia coli mediates remodelling of the eukaryotic cell surface.
TL;DR: Results show that intimin activates signal transduction pathways involved in the remodelling of the eukaryotic cell surface, probably via binding to a receptor encoded by the host cell.
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