Susan E. Campbell
Brown University
26 Papers
49 Citations
Susan E. Campbell is an academic researcher from Brown University. The author has contributed to research in topics: Medicine & Progeria. The author has an hindex of 10, co-authored 20 publications. Previous affiliations of Susan E. Campbell include University of Utah.
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Papers
Impact of Farnesylation Inhibitors on Survival in Hutchinson-Gilford Progeria Syndrome
Leslie B. Gordon,Joseph M. Massaro,Ralph B. D'Agostino,Susan E. Campbell,Joan F. Brazier,W. Ted Brown,Monica E. Kleinman,Mark W. Kieran +7 more
TL;DR: This study provides a robust untreated disease survival profile that can be used for comparisons now and in the future to assess changes in survival with treatments for Hutchinson-Gilford progeria syndrome.
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Association of Lonafarnib Treatment vs No Treatment With Mortality Rate in Patients With Hutchinson-Gilford Progeria Syndrome
Leslie B. Gordon,Leslie B. Gordon,Heather Shappell,Joseph M. Massaro,Ralph B. D'Agostino,Joan F. Brazier,Susan E. Campbell,Monica E. Kleinman,Mark W. Kieran,Mark W. Kieran +9 more
TL;DR: Among patients with HGPS, lonafarnib monotherapy, compared with no treatment, was associated with a lower mortality rate after 2.2 years of follow-up, and the association of monotherapy using the protein farnesyltransferase inhibitor lonfarnib with mortality rate was evaluated.
Family history of breast cancer. Impact on the disease experience.
TL;DR: The results suggest that women with F HOBC have a different disease experience than those without an affected relative, and healthcare providers should be aware that compliance with mammography and therapy guidelines may vary with FHOBC.
37
A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome.
Daniel Z Bar,Martin F. Arlt,Joan F. Brazier,Wendy E Norris,Susan E. Campbell,Peter S. Chines,Delphine Larrieu,Stephen P. Jackson,Francis S. Collins,Thomas W. Glover,Leslie B. Gordon,Leslie B. Gordon +11 more
TL;DR: A novel form of somatic mosaicism is reported, where a child possessed two cell populations with different HGPS disease-producing mutations of the same nucleotide—one producing severe HGPS and one mild HGPS.
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Craniofacial Abnormalities in Hutchinson-Gilford Progeria Syndrome
TL;DR: In this article, structural bone and soft-tissue cranio-facial abnormalities in HGPS through CT or MR imaging were investigated and eight newly identified abnormalities involving the calvaria, skull base, and soft tissues of the face and orbits were present with prevalences between 43% and 100%.