Susan A. Phillips
National Institutes of Health
5 Papers
56 Citations
Susan A. Phillips is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Endosome & Epidermal growth factor. The author has an hindex of 5, co-authored 5 publications.
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Papers
Overexpression of a Novel Sorting Nexin, SNX15, Affects Endosome Morphology and Protein Trafficking
TL;DR: Both the morphological and biochemical data indicate that SNX15 plays a crucial role in trafficking through the endocytic pathway, the first demonstration that a mammalian SNX protein is involved in protein trafficking.
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Rat liver membranes contain a 120 kDa glycoprotein which serves as a substrate for the tyrosine kinases of the receptors for insulin and epidermal growth factor.
TL;DR: It is demonstrated in a cell‐free system that solubilized epidermal growth factor receptors can phosphorylate tyrosine residues in 120 kDa glycoprotein.
24
Xenopus laevis contains two nonallelic preproinsulin genes. cDNA cloning and evolutionary perspective.
TL;DR: These cDNAs represent the first amphibian preproinsulin sequences to be elucidated and are believed to arose through a recent gene duplication within the amphibian radiation possibly during the development of tetraploidy in this species.
Activation of serum- and glucocorticoid-induced protein kinase (Sgk) by cyclic AMP and insulin.
TL;DR: It is demonstrated that incubation of transfected cells with 8-(4-chlorophenylthio)-cAMP led to a 2-fold activation of recombinant Sgk expressed in COS7 cells, and the combination of insulin plus 8CPT-cAMP elicited a larger response than either agent alone.
Identification and Characterization of SNX15, a Novel Sorting Nexin Involved in Protein Trafficking
TL;DR: It is proposed that overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the trans-Golgi network.