Surui Wang
3 Papers
Surui Wang is an academic researcher. The author has contributed to research in topics: Biology & Internal medicine. The author has co-authored 3 publications.
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Papers
Liver-specific depletion of an endosomal regulator causes apoptosis, cell death and liver failure
Surui Wang,Jaroslaw Cendrowski,Revathi Rekar,Karsten Motzler,Yun Kwon,Susanne Seitz,Michael Roden,Adriano Maida,Stephan Herzig,Marta Miaczynska,Anja Zeigerer +10 more
TL;DR: In this paper , the role of the endosomal regulators in liver disease was identified in the adenovirus mediated liver-specific KD in adult mice, showing that loss of this regulator induces severe liver inflammation and organ damage leading to animal lethality after 10 days of RNAi.
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.
Revathi Sekar,Karsten Motzler,Yun Kwon,Aaron Novikoff,Julia Jülg,Bahar Najafi,Surui Wang,A. Warnke,Susanne Seitz,Daniela Hass,Sofiya Gancheva,Sabine Kahl,Bin Q Yang,Brian Finan,Kathrin V. Schwarz,Juergen G. Okun,Michael Roden,Matthias Blüher,Timo D. Müller,Natalie Krahmer,Christian Behrends,Oliver Plettenburg,Marta Miaczynska,Stephan Herzig,Anja Zeigerer +24 more
TL;DR: Sekar et al. as mentioned in this paper reported that Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes and showed that changing the localization of the receptor by targeting endosomal VPS37a alters glucose production and usage downstream of glucagon, without affecting lipid metabolism.