Suping Chen
Soochow University (Suzhou)
6 Papers
2 Citations
Suping Chen is an academic researcher from Soochow University (Suzhou). The author has contributed to research in topics: Ubiquitin & Circadian clock. The author has an hindex of 5, co-authored 6 publications.
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Papers
Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1.
Suping Chen,Jing Yang,Yang Zhang,Chunyan Duan,Qing Liu,Zhengyun Huang,Ying Xu,Liang Zhou,Guoqiang Xu +8 more
TL;DR: This work identifies UBE2O as a critical regulator in the ubiquitin–proteasome system, which modulates BMAL1 transcriptional activity and circadian function by promoting BMAL 1 ubiquitination and degradation under normal physiological conditions.
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The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1
Kifayat Ullah,Suping Chen,Jiaqi Lu,Xiaohui Wang,Qing Liu,Yang Zhang,Yaqiu Long,Zhanhong Hu,Guoqiang Xu +8 more
TL;DR: The results of this work reveal that the E3 ubiquitin ligase STUB1 ubiquitinates and degrades its substrate BMAL1 and thereby alleviates hydrogen peroxide–induced cell senescence.
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Site-Specific Acetyl Lysine Antibodies Reveal Differential Regulation of Histone Acetylation upon Kinase Inhibition
TL;DR: It was found that the nature of amino acid sequences adjacent to the modification sites affected the specificity of the site-specific acetyl lysine antibodies, and acetylation of histone 3 at four lysines residues was differentially regulated by kinase inhibitors.
3
Protein C-terminal enzymatic labeling identifies novel caspase cleavages during the apoptosis of multiple myeloma cells induced by kinase inhibition.
Wenwen Duan,Suping Chen,Yang Zhang,Dan Li,Rong Wang,Shi Chen,Junbei Li,Xiaoyan Qiu,Guoqiang Xu +8 more
TL;DR: ProC‐TEL is a complementary approach to the N‐terminomics for the identification of proteolytic cleavage events such as caspase cleavages in signaling pathways, and is demonstrated to be fully optimized to provide peptide identifications comparable to N‐Terminal labeling approaches.
Deubiquitinating enzyme USP9X regulates cellular clock function by modulating the ubiquitination and degradation of a core circadian protein BMAL1.
Yang Zhang,Chunyan Duan,Jing Yang,Suping Chen,Qing Liu,Liang Zhou,Zhengyun Huang,Ying Xu,Guoqiang Xu +8 more
TL;DR: The experiments find a new regulator for circadian clock at the post-translational level and demonstrate a different regulatory function for the circadian clock through the deubiquitination and the up-regulation of the core clock protein BMAL1 in the positive limb of the transcription-translation feedback loop.