Sunshine Lahmers
Virginia–Maryland Regional College of Veterinary Medicine
30 Papers
50 Citations
Sunshine Lahmers is an academic researcher from Virginia–Maryland Regional College of Veterinary Medicine. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 12, co-authored 28 publications. Previous affiliations of Sunshine Lahmers include Washington State University & Virginia Tech.
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Papers
Calcium-dependent molecular spring elements in the giant protein titin
Dietmar Labeit,Kaori Watanabe,Christian Witt,Hideaki Fujita,Yiming Wu,Sunshine Lahmers,Theodor Funck,Siegfried Labeit,Henk Granzier +8 more
TL;DR: It is proposed that the PEVK segment contains E-rich motifs that render titin a calcium-dependent molecular spring that adapts to the physiological state of the cell.
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Developmental Control of Titin Isoform Expression and Passive Stiffness in Fetal and Neonatal Myocardium
TL;DR: Examination of titin expression and altered function during cardiac muscle development in a range of species revealed expression of fetal titin isoforms, characterized by additional spring elements both in the tandem Ig and PEVK region of the molecule.
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Genome-wide association identifies a deletion in the 3' untranslated region of Striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy
Kathryn M. Meurs,Evan Mauceli,Sunshine Lahmers,Gregory M. Acland,Stephen N. White,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh +6 more
TL;DR: It is suggested that Striatin may serve as a novel candidate gene for human ARVC, based on the fact that dogs that were homozygous for the deletion had a more severe form of disease based on a significantly higher number of ventricular premature complexes.
A splice site mutation in a gene encoding for PDK4, a mitochondrial protein, is associated with the development of dilated cardiomyopathy in the Doberman pinscher
Kathryn M. Meurs,Kathryn M. Meurs,Sunshine Lahmers,Bruce W. Keene,Stephen N. White,Stephen N. White,Mark A. Oyama,Evan Mauceli,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh +9 more
TL;DR: The identification of a splice site deletion in the PDK4 gene that is associated with the development of familial dilated cardiomyopathy in the Doberman pinscher dog is reported.
112
Expression of distinct classes of titin isoforms in striated and smooth muscles by alternative splicing, and their conserved interaction with filamins.
Siegfried Labeit,Sunshine Lahmers,Christoph Burkart,Chi Fong,Mark McNabb,Stephanie H. Witt,Christian Witt,Dietmar Labeit,Henk Granzier +8 more
TL;DR: This work showed that smooth muscle and striated muscle titins share in their conserved amino-terminal regions binding sites for alpha-actinin and filamins: Yeast two-hybrid screens using Z2-Zis1 titin baits identified prey clones coding foralpha-actInin-1 and filamin-A from smooth muscle, and alpha-Actinin-2/3, Filamin-C, and nebulin from skeletal muscle cDNA libraries,
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