27 Papers
81 Citations
Sunjoo Ahn is an academic researcher from Korea University of Science and Technology. The author has contributed to research in topics: Anaplastic lymphoma kinase & Pharmacokinetics. The author has an hindex of 8, co-authored 27 publications.
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Papers
Neurochemical and behavioral analysis by acute exposure to bisphenol A in zebrafish larvae model
Seong Soon Kim,Kyu-Seok Hwang,Jung Yoon Yang,Jin Sil Chae,Geum Ran Kim,Hyemin Kan,Myeong Hun Jung,Ha-Yeon Lee,Jin Sook Song,Sunjoo Ahn,Dae-Seop Shin,Kyeong-Ryoon Lee,Sang Kyum Kim,Myung Ae Bae +13 more
TL;DR: Comparisons in toxic responses to mammalian models highlight the utility of the zebrafish larva as a convenient model for screening environmental toxins.
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Design and characterization of cereblon-mediated androgen receptor proteolysis-targeting chimeras.
Akshay. D. Takwale,Seung-Hyun Jo,Yeong Uk Jeon,Hyung-Soo Kim,Choong Hoon Shin,Heung Kyoung Lee,Sunjoo Ahn,Chong Ock Lee,Jae Du Ha,Jeong Hoon Kim,Jeong Hoon Kim,Jong Yeon Hwang +11 more
TL;DR: The design and biological evaluation of a series of androgen receptor (AR) PROTAC degraders for the treatment of metastatic castration-resistant prostate cancer are reported, and it is shown that TD-802 effectively inhibited tumor growth in an in vivo xenograft study.
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Zebrafish as a Screening Model for Testing the Permeability of Blood-Brain Barrier to Small Molecules.
Seong Soon Kim,So Hee Im,Jung Yoon Yang,Yu-Ri Lee,Geum Ran Kim,Jin Sil Chae,Dae-Seop Shin,Jin Sook Song,Sunjoo Ahn,Byung Hoi Lee,Jae Chun Woo,Jin Hee Ahn,Chang Soo Yun,Phiho Kim,Hyoung Rae Kim,Kyeong-Ryoon Lee,Myung Ae Bae +16 more
TL;DR: The findings indicate that the zebrafish could be used as an effective screening tool during the discovery stages of new drugs to estimate their distribution in the brain.
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Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera.
Kidae Kim,Dong-Ho Lee,Sungryul Park,Sungryul Park,Seung-Hyun Jo,Seung-Hyun Jo,Bonsu Ku,Sung Goo Park,Sung Goo Park,Byoung Chul Park,Byoung Chul Park,Yeong Uk Jeon,Sunjoo Ahn,Chung Hyo Kang,Daehee Hwang,Sehyun Chae,Jae Du Ha,Sunhong Kim,Sunhong Kim,Jong Yeon Hwang,Jeong Hoon Kim,Jeong Hoon Kim +21 more
TL;DR: VHL-CRBN heterodimerizing PROTACs are developed that induce the degradation of CRBN, but not VHL, suggesting that the intrinsically disordered region of targeted proteins is essential for efficient proteolysis, providing a novel criterion for choosing degradable protein targets.
SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function
Mihyun Bae,Junyeop Daniel Roh,You-Joung Kim,Seong Soon Kim,Hye Min Han,Esther Yang,Hyojin Kang,Suho Lee,Jin Yong Kim,Ryeonghwa Kang,Hwajin Jung,Taesun Yoo,Hyo Sang Kim,Doyoun Kim,Heejeong Oh,Sungwook Han,Dayeon Kim,Jinju Han,Yong Chul Bae,Hyun Kim,Sunjoo Ahn,Andrew K Chan,Daeyoup Lee,Jin Woo Kim,Eunjoon Kim +24 more
TL;DR: In this article, SLC6A20A, an amino acid transporter known to transport proline based on in vitro data but is understudied in the brain, regulates proline and glycine levels and NMDAR function in the mouse brain.
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