Sunit Mandad
University of Göttingen
12 Papers
18 Citations
Sunit Mandad is an academic researcher from University of Göttingen. The author has contributed to research in topics: Biology & Centrosome. The author has an hindex of 8, co-authored 11 publications. Previous affiliations of Sunit Mandad include Max Planck Society.
Chat about Author
Papers
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins
Benjamin G. Wilhelm,Sunit Mandad,Sven Truckenbrodt,Katharina Kröhnert,Christina Schäfer,Burkhard Rammner,Seong Joo Koo,Gala A. Claßen,Michael Krauss,Volker Haucke,Henning Urlaub,Henning Urlaub,Silvio O. Rizzoli +12 more
TL;DR: A quantitative molecular-scale image of the “average” synapse populated with realistic renditions of each of the protein components that contribute to the inner workings of neurons is presented, displaying 300,000 proteins in atomic detail.
Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions
Eugenio F. Fornasiero,Sunit Mandad,Sunit Mandad,Hanna Wildhagen,Mihai Alevra,Burkhard Rammner,Sarva Keihani,Felipe Opazo,Inga Urban,Till Ischebeck,M. Sadman Sakib,Maryam K. Fard,Koray Kirli,Tonatiuh Pena Centeno,Ramon O. Vidal,Raza-Ur Rahman,Eva Benito,Andre Fischer,Andre Fischer,Sven Dennerlein,Sven Dennerlein,Peter Rehling,Peter Rehling,Ivo Feussner,Stefan Bonn,Stefan Bonn,Mikael Simons,Henning Urlaub,Henning Urlaub,Silvio O. Rizzoli +29 more
TL;DR: This work uses isotopic labeling with mass spectrometry and mathematical modeling to accurately determine protein lifetimes in the mouse brain, providing a large set of biologically significant observations, including pathway-, organelle-, organ-, or cell-specific effects, along with a comprehensive catalog of extremely long-lived proteins (ELLPs).
BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions
Maryam K. Fard,Franziska van der Meer,Paula Sánchez,Ludovico Cantuti-Castelvetri,Sunit Mandad,Sunit Mandad,Sarah Jäkel,Eugenio F. Fornasiero,Sebastian Schmitt,Marc Ehrlich,Marc Ehrlich,Laura Starost,Laura Starost,Tanja Kuhlmann,Christina Sergiou,Verena Schultz,Claudia Wrzos,Wolfgang Brück,Henning Urlaub,Henning Urlaub,Leda Dimou,Leda Dimou,Christine Stadelmann,Mikael Simons +23 more
TL;DR: This work identifies a means to map ongoing myelin formation in health and disease and presents a potential cellular target for remyelination therapies in MS.
A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines.
Martin S. Helm,Martin S. Helm,Tal M Dankovich,Tal M Dankovich,Sunit Mandad,Burkhard Rammner,Sebastian Jähne,Sebastian Jähne,Vanessa Salimi,Christina Koerbs,Richard Leibrandt,Henning Urlaub,Henning Urlaub,Thomas Schikorski,Silvio O. Rizzoli +14 more
TL;DR: In this article, the authors combined electron microscopy and quantitative biochemistry with super-resolution microscopy to annotate more than 47,000 spines for more than 100 synaptic targets.
88
The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43
Sarva Keihani,Verena Kluever,Sunit Mandad,Vikas Bansal,Raza-Ur Rahman,E. Fritsch,L. Caldi Gomes,Annette Gärtner,S. Kügler,Henning Urlaub,Henning Urlaub,J. D. Wren,Stefan Bonn,Silvio O. Rizzoli,Eugenio F. Fornasiero +14 more
TL;DR: The effects of neuroLNC on synaptic vesicle release require interaction with the RNA-binding protein TDP-43 (TAR DNA binding protein-43) and the selective stabilization of mRNAs encoding for presynaptic proteins.
50