Sundar Suresh
Veterans Health Administration
6 Papers
87 Citations
Sundar Suresh is an academic researcher from Veterans Health Administration. The author has contributed to research in topics: Oxysterol & Neuroglia. The author has an hindex of 5, co-authored 6 publications.
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Papers
The Niemann-Pick C1 Protein Resides in a Vesicular Compartment Linked to Retrograde Transport of Multiple Lysosomal Cargo
Edward B. Neufeld,Meryl E. Wastney,Shutish C. Patel,Sundar Suresh,Adele Cooney,Nancy K. Dwyer,Calvin F. Roff,Kousaku Ohno,Jill A. Morris,Eugene D. Carstea,John P. Incardona,Jerome F. Strauss,Marie T. Vanier,Marc C. Patterson,Roscoe O. Brady,Peter G. Pentchev,E. Joan Blanchette-Mackie +16 more
TL;DR: It is concluded that a distinctive organelle containing NPC1 mediates retrograde lysosomal transport of endocytosed cargo that is not restricted to sterol.
388
Cellular cholesterol storage in the Niemann-Pick disease type C mouse is associated with increased expression and defective processing of apolipoprotein D.
TL;DR: Investigation of expression and cellular processing of apoD in the Niemann‐Pick type C mouse, an animal model of human NPC, reveals hitherto unrecognized defects in apiD metabolism in NPC that appear to be linked to the known defects in cholesterol homeostasis in this disorder.
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25-hydroxycholesterol induces reorganization of lysosomes in normal but not-Niemann-Pick disease type C astrocytes
TL;DR: Results show that lysosomal cholesterol storage in NPC astrocytes is associated with a block in oxysterol-mediated fibrillar reorganization of lysoome associated membrane glycoprotein (LAMP).
6
Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.
Ujendra Kumar,Ramakrishnan Sasi,Sundar Suresh,Amit Patel,Muthusamy Thangaraju,Peter Metrakos,Shutish C. Patel,Yogesh C. Patel +7 more
TL;DR: Analysis of pattern of expression of hSSTR1-5 in normal human islet cells by quantitative double-label confocal fluorescence immunocytochemistry reveals predominant expression of SSTR1, SSTR2, and SSTR5 in human islets, which could be the basis for preferential insulin suppression by Sstr1-specific ligands and of glucagon inhibition by SStr2-selective compounds.