Sun-Ju Yi
Children's Hospital Los Angeles
7 Papers
57 Citations
Sun-Ju Yi is an academic researcher from Children's Hospital Los Angeles. The author has contributed to research in topics: breakpoint cluster region & GTPase-activating protein. The author has an hindex of 6, co-authored 7 publications.
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Papers
TGFβ signaling plays a critical role in promoting alternative macrophage activation
TL;DR: A novel biological role for TGFβ signaling is established in controlling expression of genes characteristic for alternatively activated macrophages, possibly explaining the systemic inflammation observed in Vav1-Cre x TβRIIfx/fx mice.
412
Bcr and Abr Cooperate in Negatively Regulating Acute Inflammatory Responses
Jess M. Cunnick,Sabine Schmidhuber,Gang Chen,Min Yu,Sun-Ju Yi,YoungJin Cho,Vesa Kaartinen,Parviz Minoo,David Warburton,John Groffen,John Groffen,Nora Heisterkamp,Nora Heisterkamp +12 more
TL;DR: The data show that Abr and Bcr normally curb very specific functions of mature tissue innate immune cells, and that each protein has distinct as well as partly overlapping functions in the downregulation of inflammatory processes.
33
Environment-mediated drug resistance in Bcr/Abl-positive acute lymphoblastic leukemia
Niklas Feldhahn,Anna Arutyunyan,Sonia Stoddart,Bin Zhang,Sabine Schmidhuber,Sun-Ju Yi,Yong-Mi Kim,John Groffen,Nora Heisterkamp +8 more
TL;DR: It is concluded that development of EMDR by ALL cells involves changes in numerous intracellular pathways and development of tolerance to drugs such as nilotinib may therefore be circumvented by simultaneous treatment with other drugs having divergent targets.
24
Transglutaminase 2 regulates the GTPase-activating activity of Bcr.
TL;DR: In this paper, a protein-protein interaction with transglutaminase 2 (TG2) was found to prevent Bcr activity and increased levels of active GTP-bound Rac and EGF-stimulated membrane ruffling.
14
Bcr is a substrate for Transglutaminase 2 cross-linking activity.
TL;DR: It is reported that activation of TG2 by calcium caused the formation of covalently cross-linked Bcr, which represents both an interacting partner under non-stressed conditions and a target of transglutaminase activity for TG2 during extreme stress.