Hand gesture recognition systems (HGR) based on electromyography signals (EMGs) and inertial measurement unit signals (IMUs) have been studied for different applications in recent years. Most commonly, cutting-edge HGR methods are based on supervised machine learning methods. However, the potential benefits of reinforcement learning (RL) techniques have shown that these techniques could be a viable option for classifying EMGs. Methods based on RL have several advantages such as promising classification performance and online learning from experience. In this work, we developed an HGR system made up of the following stages: pre-processing, feature extraction, classification, and post-processing. For the classification stage, we built an RL-based agent capable of learning to classify and recognize eleven hand gestures—five static and six dynamic—using a deep Q-network (DQN) algorithm based on EMG and IMU information. The proposed system uses a feed-forward artificial neural network (ANN) for the representation of the agent policy. We carried out the same experiments with two different types of sensors to compare their performance, which are the Myo armband sensor and the G-force sensor. We performed experiments using training, validation, and test set distributions, and the results were evaluated for user-specific HGR models. The final accuracy results demonstrated that the best model was able to reach up to 97.50%±1.13% and 88.15%±2.84% for the classification and recognition, respectively, with regard to static gestures, and 98.95%±0.62% and 90.47%±4.57% for the classification and recognition, respectively, with regard to dynamic gestures with the Myo armband sensor. The results obtained in this work demonstrated that RL methods such as the DQN are capable of learning a policy from online experience to classify and recognize static and dynamic gestures using EMG and IMU signals.

https://www.mdpi.com/1424-8220/22/24/9613/pdf?version=1670486753

Hand Gesture Recognition Using EMG-IMU Signals and Deep Q-Networks

ABSTRACT The CRISPR-Cas system stands out as a promising genome editing tool due to its cost-effectiveness and time efficiency compared to other methods. This system has tremendous potential for treating various diseases, including genetic disorders and cancer, and promotes therapeutic research for a wide range of genetic diseases. Additionally, the CRISPR-Cas system simplifies the generation of animal models, offering a more accessible alternative to traditional methods. The CRISPR-Cas9 system can be used to cleave target DNA strands that need to be corrected, causing double-strand breaks (DSBs). DNA with DSBs can then be recovered by the DNA repair pathway that the CRISPR-Cas9 system uses to edit target gene sequences. High cleavage efficiency of the CRISPR-Cas9 system is thus imperative for effective gene editing. Herein, we explore several factors affecting the cleavage efficiency of the CRISPR-Cas9 system. These factors include the GC content of the protospacer-adjacent motif (PAM) proximal and distal regions, single-guide RNA (sgRNA) properties, and chromatin state. These considerations contribute to the efficiency of genome editing.

Factors affecting the cleavage efficiency of the CRISPR-Cas9 system

One in every five occupational deaths occurs in the construction sector. A proactive approach for improving on-site safety is identifying and analyzing accident precursors, such as near-misses, that provide early warnings of accidents. Despite the importance of near-misses, they are frequently left unreported and unrecorded in the construction sector. The adoption of modern technologies can prevent accidents by automated data collection and analysis. This study aims to develop near-miss detection metrics to facilitate the automated detection of near-misses through sensors. The study adopted a mixed method approach including both qualitative and quantitative approaches. First, a quantifiable definition of near-misses was developed from the literature. Hazards, accidents, and the causes of accidents were identified. Through empirical and statistical analyses of accidents from the OSHA repository, combinations of unsafe acts and conditions responsible for a near-miss were identified. The identified factors were analyzed using a frequency analysis, correlation, and a lambda analysis. The results revealed twelve significant near-misses, such as A1—approach to restricted areas and C2—unguarded floor/roof openings, A5—equipment and tool inspection was incomplete and C8—unsafely positioned ladders and scaffolds, A2—no or improper use of PPE and C2—unguarded floor or roof openings, etc. Lastly, measurable data required by sensors for autonomous detection of near-misses were determined. The developed metric set the basis for automating near-miss reporting and documentation using modern sensing technology to improve construction safety. This study contributes to improving construction safety by addressing the underreporting of near-miss events. Overall, the developed metrics lay the groundwork for enhancing construction safety through automated near-miss reporting and documentation. Furthermore, it helps for the establishment of safety management schemes in the construction industry, specifically in identifying near-misses. This research offers valuable insight into developing guidelines for safety managers to improve near-miss reporting and detection on construction sites. In sum, the findings can be valuable for other industries also looking to establish or assess their own safety management systems.

Near-Miss Detection Metrics: An Approach to Enable Sensing Technologies for Proactive Construction Safety Management

Accidental falls represent a major cause of fatal injuries for construction workers. Failure to seek medical attention after a fall can significantly increase the risk of death for construction workers. Wearable sensors, computer vision, and manual techniques are common modalities for detecting worker falls in the literature. However, they are severely constrained by issues such as cost, lighting, background, clutter, and privacy. To address the problems associated with the existing proposed methods, a new method has been conceived to identify construction worker falls by analyzing the CSI signals extracted from commercial Wi-Fi routers. In this research context, our study aimed to investigate the potential of using Channel State Information (CSI) to identify falls among construction workers. To achieve the aim of this study, CSI data corresponding to 360 sets of activities were collected from six construction workers on real construction sites. The results indicate that (1) the behavior of construction workers is highly correlated with the magnitude of CSI, even in real construction sites, and (2) the CSI-based method for identifying construction worker falls has an accuracy of 99% and can also accurately distinguish between falls and fall-like actions. The present study makes a significant contribution to the field by demonstrating the feasibility of utilizing low-cost Wi-Fi routers for the continuous monitoring of fall incidents among construction workers. To the best of our knowledge, this is the first investigation to address the issue of fall detection using commercial Wi-Fi devices in real-world construction environments. Considering the dynamic nature of construction sites, the new method developed in this study helps to detect falls at construction sites automatically and helps injured construction workers to seek medical attention on time.

/pdf/feasibility-analysis-of-using-channel-state-information-csi-39r5cttt.pdf

Feasibility Analysis of Using Channel State Information (CSI) Acquired from Wi-Fi Routers for Construction Worker Fall Detection

Monitoring and evaluating the status and behaviour of construction workers using wearable sensing technologies

Workers at construction sites are prone to fall-from-height (FFH) accidents. The severity of injury can be represented by the acceleration peak value. In the study, a risk prediction against FFH was made using IMU sensor data for accident prevention at construction sites. Fifteen general working movements (NF: non-fall), five low-hazard-fall movements, (LF), and five high-hazard-FFH movements (HF) were performed by twenty male subjects and a dummy. An IMU sensor was attached to the T7 position of the subject to measure the three-axis acceleration and angular velocity. The peak acceleration value, calculated from the IMU data, was 4 g or less in general work movements and 9 g or more in FFHs. Regression analysis was performed by applying various deep learning models, including 1D-CNN, 2D-CNN, LSTM, and Conv-LSTM, to the risk prediction, and then comparing them in terms of their mean absolute error (MAE) and mean squared error (MSE). The FFH risk level was estimated based on the predicted peak acceleration. The Conv-LSTM model trained by MAE showed the smallest error (MAE: 1.36 g), and the classification with the predicted peak acceleration showed the best accuracy (97.6%). This study successfully predicted the FFH risk levels and could be helpful to reduce fatal injuries at construction sites.

/pdf/fall-from-height-detection-using-deep-learning-based-on-imu-2f436zng.pdf

Fall-from-Height Detection Using Deep Learning Based on IMU Sensor Data for Accident Prevention at Construction Sites

Spinal infection caused by Coxiella burnetii is rare and difficult to diagnose. Here we reported a case of spinal infection from Coxiella burnetii detected by the metagenomic next-generation sequencing (mNGS).A 66-year-old male farmer with no medical history reported severe sharp low back pain, numbness and lower limb weakness for three years. Magnetic resonance imaging (MRI) revealed bone destruction and spinal cord compression within L1 and L2. mNGS testing showed that the inspected specimen collected from spinal lesion was detected positively for Coxiella burnetii. After receiving the combined treatment of antibiotic therapy and surgical intervention, the patient recovered well, and the sagittal MRI showed that vertebral edema signals disappeared and the graft of bone fused 16 months after surgery.The mNGS may be benefit for early diagnosis and intervention of non-specific spinal infection, and future studies should validate its effectiveness for clinical use in spinal infections. Additionally, antibiotic therapy combined with surgical intervention plays an important role on the treatment of spinal infection caused by Coxiella burnetii. 

/pdf/spinal-infection-caused-by-coxiella-burnetii-3vsc6ehq.pdf

Spinal infection caused by Coxiella burnetii

sEMG-based gesture recognition is useful for human–computer interactions, especially for technology supporting rehabilitation training and the control of electric prostheses. However, high variability in the sEMG signals of untrained users degrades the performance of gesture recognition algorithms. In this study, the hand posture recognition algorithm and radar plot-based visual feedback training were developed using multichannel sEMG sensors. Ten healthy adults and one bilateral forearm amputee participated by repeating twelve hand postures ten times. The visual feedback training was performed for two days and five days in healthy adults and a forearm amputee, respectively. Artificial neural network classifiers were trained with two types of feature vectors: a single feature vector and a combination of feature vectors. The classification accuracy of the forearm amputee increased significantly after three days of hand posture training. These results indicate that the visual feedback training efficiently improved the performance of sEMG-based hand posture recognition by reducing variability in the sEMG signal. Furthermore, a bilateral forearm amputee was able to participate in the rehabilitation training by using a radar plot, and the radar plot-based visual feedback training would help the amputees to control various electric prostheses.

https://www.mdpi.com/1424-8220/22/20/7984/pdf?version=1666694438

sEMG-Based Hand Posture Recognition and Visual Feedback Training for the Forearm Amputee

Neurodegenerative diseases result from the interplay of abnormal gene expression and various pathological factors. Therefore, a disease‐specific integrative genetic approach is required to understand the complexities and causes of target diseases. Recent studies have identified the correlation between genes encoding several transmembrane proteins, such as the cluster of differentiation (CD) and Alzheimer's disease (AD) pathogenesis. In this study, CD48 and CD40 gene expression in AD, a neurodegenerative disease, was analyzed to infer this link. Total RNA sequencing was performed using an Alzheimer's disease mouse model brain and blood, and gene expression was determined using a genome‐wide association study (GWAS). We observed a marked elevation of CD48 and CD40 genes in Alzheimer's disease. Indeed, the upregulation of both CD48 and CD40 genes was significantly increased in the severe Alzheimer's disease group. With the elevation of CD48 and CD40 genes in Alzheimer's disease, associations of protein levels were also markedly increased in tissues. In addition, overexpression of CD48 and CD40 genes triggered tau aggregation, and co‐expression of these genes accelerated aggregation. The nuclear factor kappa B (NF‐ĸB) signaling pathway was enriched by CD48 and CD40 gene expression: it was also associated with tau pathology. Our data suggested that the CD48 and CD40 genes are novel AD‐related genes, and this approach may be useful as a diagnostic or therapeutic target for the disease.

Boosting of tau protein aggregation by CD40 and CD48 gene expression in Alzheimer's disease

Abstract Phospholipase C (PLC) is an essential isozyme involved in the phosphoinositide signalling pathway, which maintains cellular homeostasis. Gain- and loss-of-function mutations in PLC affect enzymatic activity and are therefore associated with several disorders. Alternative splicing variants of PLC can interfere with complex signalling networks associated with oncogenic transformation and other diseases, including brain disorders. Cells and tissues with various mutations in PLC contribute different phosphoinositide signalling pathways and disease progression, however, identifying cryptic mutations in PLC remains challenging. Herein, we review both the mechanisms underlying PLC regulation of the phosphoinositide signalling pathway and the genetic variation of PLC in several brain disorders. In addition, we discuss the present challenges associated with the potential of deep-learning-based analysis for the identification of PLC mutations in brain disorders.

/pdf/cryptic-mutations-of-plc-family-members-in-brain-disorders-gr026u0p.pdf

Cryptic mutations of PLC family members in brain disorders: recent discoveries and a deep-learning-based approach

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Sumin S Yang

Author Tools

Chat about Author