Suman Ghosh

TL;DR: It is demonstrated that the Hsp 90 cochaperone, activator of Hsp90 ATPase homolog 1 (Aha1), dramatically increases the production of aggregated tau in vitro and in a mouse model of neurodegenerative disease, and suggests that therapeutics targeting Aha1 may reduce toxic tau oligomers and slow or prevent neurodegenersative disease progression.

TL;DR: The physiological conditions which regulate the production of the aromatic alcohols, i.e., phenethyl alcohol, tyrosol, and tryptophol are examined, consistent with aromatic alcohol production—aromatic transaminases (gene products for ARO8 and ARO9), aromatic decarboxylase (ARO10), and alcohol dehydrogenase (ADH)—via the fusel oil pathway.

TL;DR: It is proposed that in addition to being a virulence factor, gliotoxin may also provide an advantage to A. fumigatus when infecting a host that harbors other opportunistic fungi.

TL;DR: These findings argue that a Zap1- and zinc-dependent signal affects the yeast-hypha balance and that it is operative in the low-farnesol environment of the zap1Δ/Δ biofilm and indicate that Zap1 is a positive regulator of farnesol accumulation.