21 Papers
40 Citations
Suh Lee is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Atrophy & Alzheimer's disease. The author has an hindex of 17, co-authored 21 publications.
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Papers
Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: an MRI study of 676 AD, MCI, and normal subjects
Xue Hua,Alex D. Leow,Neelroop N. Parikshak,Suh Lee,Ming Chang Chiang,Arthur W. Toga,Clifford R. Jack,Michael W. Weiner,Paul M. Thompson +8 more
TL;DR: Baseline temporal lobe atrophy correlated with current cognitive performance, future cognitive decline, and conversion from MCI to AD over the following year; it predicted future decline even in healthy subjects.
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Voxelwise genome-wide association study (vGWAS)
Jason L. Stein,Xue Hua,Suh Lee,April J. Ho,Alex D. Leow,Arthur W. Toga,Andrew J. Saykin,Li Shen,Tatiana Foroud,Nathan Pankratz,Matthew J. Huentelman,David Craig,Jill D. Gerber,April N. Allen,Jason J. Corneveaux,Bryan M. DeChairo,Steven G. Potkin,Michael W. Weiner,Paul M. Thompson +18 more
TL;DR: This is the first voxelwise genome wide association study to the authors' knowledge, and offers a novel method to discover genetic influences on brain structure by studying only the most associated variant at each voxels.
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A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
April J. Ho,Jason L. Stein,Xue Hua,Suh Lee,Derrek P. Hibar,Alex D. Leow,Ivo D. Dinov,Arthur W. Toga,Andrew J. Saykin,Li Shen,Tatiana Foroud,Nathan Pankratz,Matthew J. Huentelman,David Craig,Jill D. Gerber,April N. Allen,Jason J. Corneveaux,Dietrich A. Stephan,Charles DeCarli,Bryan M. DeChairo,Steven G. Potkin,Clifford R. Jack,Michael Weiner,Michael Weiner,Cyrus A. Raji,Oscar L. Lopez,James T. Becker,Owen Carmichael,Paul M. Thompson +28 more
TL;DR: 3D maps of regional brain volume differences in 206 healthy elderly subjects scanned with MRI and genotyped as part of the Alzheimer's Disease Neuroimaging Initiative reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly.
Obesity is linked with lower brain volume in 700 AD and MCI patients.
April J. Ho,Cyrus A. Raji,James T. Becker,Oscar L. Lopez,Lewis H. Kuller,Xue Hua,Suh Lee,Derrek P. Hibar,Ivo D. Dinov,Jason L. Stein,Clifford R. Jack,Michael Weiner,Michael Weiner,Arthur W. Toga,Paul M. Thompson +14 more
TL;DR: In both AD and MCI groups, higher body mass index was associated with brain volume deficits in frontal, temporal, parietal, and occipital lobes; the atrophic pattern was consistent in both ADNI and CHS populations.
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Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease.
Jason L. Stein,Xue Hua,Jonathan H. Morra,Suh Lee,Derrek P. Hibar,April J. Ho,Alex D. Leow,Arthur W. Toga,Jae Hoon Sul,Hyun Min Kang,Eleazar Eskin,Andrew J. Saykin,Li Shen,Tatiana Foroud,Nathan Pankratz,Matthew J. Huentelman,David Craig,Jill D. Gerber,April N. Allen,Jason J. Corneveaux,Dietrich A. Stephan,Jennifer Webster,Bryan M. DeChairo,Steven G. Potkin,Clifford R. Jack,Michael Weiner,Michael Weiner,Paul M. Thompson +27 more
TL;DR: The 3D profile of temporal lobe volume differences in 742 brain MRI scans of Alzheimer's disease patients, mildly impaired, and healthy elderly subjects is mapped to reveal intense temporal lobe effects, demonstrating a negative effect on global cognitive function.
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