The recently “pictured” pair of Nano domains (NDs) interacting coherently in time was used here to further delineate ND-behavior and develop the structure of coherence domains of increasing size. This extension started with two pairs, then four, later with many more which eventually produced a “solid” sheath (containing coherent squares or rectangles within each other). These solid sheaths are stacked atop of each other forming a solid multi-layered “raft-like structure” called Coherent Domain (CD) (ranging in size from 1 μm to several μ m). It is our proposal that these CDs would then be fitting into specific cavities within organisms where their shape may need to adjust to the environment. Very little is known about the latter and how everything interacts in a living system. Various possibilities including experimental approaches are discussed.

Coherence Domains in Living Systems

The impact of the protein-rich in vivo environment on targeted binding of functionalized nanoparticles has been an active field of research over the past several years. Current research aims at better understanding the nature of the protein corona and how it may be possible for targeted binding to occur even in the presence of serum. Much of the current research focuses on nanoparticles targeted to particular cell receptors or features with the aim of cellular uptake. However, similar research has not been performed on nanoparticles that are targeted to nonprotein disease features, such as hydroxyapatite (HA). HA is a crystalline calcium-phosphate mineral that is present in large quantities in bone and, in smaller quantities, in diseased cardiovascular tissue in cases of atherosclerosis or various stenoses. Our work aims to gain a better understanding of the behavior of PEGylated, peptide-coated superparamagnetic iron oxide nanoparticles (SPIONs) in a biologically relevant high-protein environment (50% se...

/pdf/targeted-nanoparticle-binding-to-hydroxyapatite-in-a-high-49bjr80are.pdf

Targeted Nanoparticle Binding to Hydroxyapatite in a High Serum Environment for Early Detection of Heart Disease.

Small-angle neutron scattering (SANS) has been used to study the aggregation of anionic silica nanoparticles as induced through different interactions. The nanoparticle aggregation is induced by addition of salt (NaCl), cationic protein (lysozyme) and non-ionic surfactant (C12E10) employing different kind of interactions. The results show that the interaction in presence of salt can be explained using DLVO theory whereas non-DLVO forces play important role for interaction of nanoparticles with protein and surfactant. The presence of salt screens the repulsion between charged nanoparticles giving rise to a net attraction in the DLVO potential. On the other hand, strong electrostatic attraction between nanoparticle and oppositely charged protein leads to protein-mediated nanoparticle aggregation. In case of non-ionic surfactant, the relatively long-range attractive depletion interaction is found to be responsible for the particle aggregation. Interestingly, the completely different interactions lead to simi...

/pdf/aggregation-in-charged-nanoparticles-solutions-induced-by-1t0sfkpz7j.pdf

Aggregation in charged nanoparticles solutions induced by different interactions

Small-angle neutron scattering (SANS) and dynamic light scattering (DLS) studies have been carried out to study interaction of anionic nanoparticles with uncharged (non-ionic) C12E10 micelles. DLS results show increase in the effective size of nanoparticles on addition of C12E10. Contrast variation SANS confirms the micelles decoration of nanoparticles which is believed to be driven by the hydrogen bonding between them. The number of adsorbed micelles per nanoparticle increases with the increase in the nanoparticle size. Surface number density is also found to be increasing with increase in particle size indicating favored adsorption for larger curvature.

/pdf/probing-interaction-of-charged-nanoparticles-with-uncharged-2q2usyrdxp.pdf

Probing interaction of charged nanoparticles with uncharged micelles

The structure and kinetics during aggregation of anionic silica nanoparticles as induced through different mechanisms have been studied by dynamic light scattering (DLS) and small-angle neutron scattering (SANS) Three different additives, namely an electrolyte (NaCl), cationic protein (lysozyme) and non-ionic surfactant (C12E10) were used to initiate nanoparticle aggregation Electrolyte induced aggregation can be explained by DLVO interaction, whereas depletion interaction (non-DLVO interaction) is found responsible for nanoparticle aggregation in case of non-ionic surfactant Unlike these two cases, strong electrostatic attraction between nanoparticle and oppositely charged protein results into protein-mediated nanoparticle aggregation The electrolyte induced aggregation show quite slow aggregation rate whereas protein mediated as well as surfactant induced aggregation takes place almost instantaneously The significant differences observed in the kinetics are explained based on range of interactions 

/pdf/kinetics-of-aggregation-in-charged-nanoparticle-solutions-4zenj1xlen.pdf

Kinetics of aggregation in charged nanoparticle solutions driven by different mechanisms

Small-angle neutron scattering has been used to study the interaction of silica nanoparticle with Bovine Serum Albumin (BSA) protein without and with a protein denaturing agent urea. The measurements have been carried out at pH 7 where both the components (nanoparticle and protein) are similarly charged. We show that the interactions in nanoparticle-protein system can be modified by changing the conformation of protein through the presence of urea. In the absence of urea, the strong electrostatic repulsion between the nanoparticle and protein prevents protein adsorption on nanoparticle surface. This non-adsorption, in turn gives rise to depletion attraction between nanoparticles. However, with addition of urea the depletion attraction is completely suppressed. Urea driven denaturation of protein is utilized to expose the positively charged patched of the BSA molecules which eventually leads to adsorption of BSA on nanoparticles eliminating the depletion interaction.

/pdf/modifications-in-nanoparticle-protein-interactions-by-1vc4yjkrb7.pdf

Modifications in nanoparticle-protein interactions by varying the protein conformation

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Sugam Kumar

Author Tools

Chat about Author

Papers

Aggregation in charged nanoparticles solutions induced by different interactions

Probing interaction of charged nanoparticles with uncharged micelles

Kinetics of aggregation in charged nanoparticle solutions driven by different mechanisms

Modifications in nanoparticle-protein interactions by varying the protein conformation