Sue Michalek
University of Alabama at Birmingham
7 Papers
3 Citations
Sue Michalek is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Exosome & Myeloid-derived Suppressor Cell. The author has an hindex of 6, co-authored 7 publications.
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Papers
Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance
Zhongbin Deng,Anton Poliakov,Robert W. Hardy,Ronald H. Clements,Cunren Liu,Yuelong Liu,Jianhua Wang,Xiaoyu Xiang,Shuangqin Zhang,Xiaoying Zhuang,Spandan V. Shah,Dongmei Sun,Sue Michalek,William E. Grizzle,Timothy W Garvey,James A. Mobley,Huang-Ge Zhang +16 more
TL;DR: ELVs released by adipose tissue can act as a mode of communication between adipose tissues and macrophages and insulin resistance requires the TLR4/TRIF pathway.
513
Contribution of MyD88 to the Tumor Exosome-Mediated Induction of Myeloid Derived Suppressor Cells
Yuelong Liu,Xiaoyu Xiang,Xiaoyu Xiang,Xiaoying Zhuang,Xiaoying Zhuang,Shuangyin Zhang,Cunren Liu,Ziqiang Cheng,Sue Michalek,William E. Grizzle,Huang-Ge Zhang,Huang-Ge Zhang,Huang-Ge Zhang +12 more
TL;DR: In this paper, the authors observed that mice pretreated with tumor exosomes had a significant acceleration of tumor metastasis in the lung, which correlated significantly with an increase in recruitment of more Myeloid-derived suppressor cells (MDSCs) in the lungs of C57BL/6j (B6) mice.
225
TLR2-mediated expansion of MDSCs is dependent on the source of tumor exosomes.
Xiaoyu Xiang,Yuelong Liu,Xiaoyin Zhuang,Shuangqin Zhang,Sue Michalek,Douglas D. Taylor,William E. Grizzle,Huang-Ge Zhang +7 more
TL;DR: The results suggest that exosomes released from tumor cells that are not within a tumor microenvironment may not realistically represent the role of tumor exosome-mediated inflammatory responses in vivo.
89
Phospholipase Cγ2 Mediates RANKL-stimulated Lymph Node Organogenesis and Osteoclastogenesis
Yabing Chen,Xiaohong Wang,Lie Di,Guoping Fu,Yuhong Chen,Li Bai,Jianzhong Liu,Xu Feng,Jay M. McDonald,Jay M. McDonald,Sue Michalek,Yinghong He,Mei Yu,Yang Xin Fu,Renren Wen,Hui Wu,Demin Wang +16 more
TL;DR: PLCγ2 is essential for RANK signaling, and its deficiency leads to defective lymph node organogenesis and osteoclast differentiation, and re-introduction of P LCγ2 but not PLCγ1 restores RANKL-mediated osteocline differentiation of PLCα-deficient bone marrow-derived monocyte/macrophage.
31
TLR4 regulates pulmonary vascular homeostasis and remodeling via redox signaling.
Liping Ma,Namasivayam Ambalavanan,Hui Liu,Yong Sun,Nirag Jhala,Wayne E. Bradley,Louis J. Dell'Italia,Sue Michalek,Hui Wu,Chad Steele,Raymond L. Benza,Yabing Chen +11 more
TL;DR: Inhibition of TLR4, by genetic ablation or hypoxia, increases the expression of Nox1/Nox4 and induces PASMC proliferation and vascular remodeling, which support a novel function ofTLR4 in regulating the development of PAH and reveal a new regulatory axis contributing to TLR 4 deficiency-induced vascular hypertrophy and remodeling.