112 Papers
682 Citations
Sue Hwa Lin is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Prostate cancer & Bone metastasis. The author has an hindex of 35, co-authored 101 publications. Previous affiliations of Sue Hwa Lin include University of Texas at Austin & University of Texas Health Science Center at Houston.
Chat about Author
Papers
KDM4A promotes the progression of neuroendocrine prostate cancer
Celia S. L. Mak,Ming Zhu,Xin Liang,Feng Wang,Fei Yuan,Anh Hoang,Xingzhi Song,Peter Shepherd,Derek Liang,Jessica Suh,Jiwon Park,Miao Zhang,Eric Metzger,Roland Schüle,Abhinav K. Jain,Ellen Karasik,Barbara A. Foster,Min Gyu Lee,Paul G. Corn,Christopher J. Logothetis,Ana Aparicio,Nora M. Navone,Patricia Troncoso,Zhi Tan,Jian Zhang,Sue Hwa Lin,Guocan Wang +26 more
TL;DR: In this paper , the authors identified histone lysine demethylase KDM4A as a key player in prostate cancer progression and an effective therapeutic target, and demonstrated that inhibition of kDM4a significantly impairs NEPC cell growth in preclinical models.
A Phase II Study of Cabozantinib and Androgen Ablation in Patients with Hormone-Naïve Metastatic Prostate Cancer
Paul G. Corn,Miao Zhang,Graciela M. Nogueras-Gonzalez,Lianchun Xiao,Amado J. Zurita,Sumit K. Subudhi,Shi Ming Tu,Ana Aparicio,Cristian Coarfa,Kimal Rajapakshe,Shixia Huang,Nora M. Navone,Sue Hwa Lin,Guocan Wang,Sumankalai Ramachandran,Mark Titus,Theocharis Panaretakis,Gary E. Gallick,Eleni Efstathiou,Patricia Troncoso,Christopher J. Logothetis +20 more
TL;DR: Analysis of baseline cytokine and angiogenic factors revealed that higher plasma concentrations of Lumican, CXCL5, CD25, and CD30 were associated with shorter PFS as was high tumor expression of pFGFR1.
Angiomotin is a novel component of cadherin-11/β-catenin/p120 complex and is critical for cadherin-11-mediated cell migration
Angelica Ortiz,Yu Chen Lee,Guoyu Yu,Hsuan Chen Liu,Song Chang Lin,Melmet Asim Bilen,Hyojin Cho,Li Yuan Yu-Lee,Sue Hwa Lin +8 more
TL;DR: Using the human Cad11 cytoplasmic domain in pulldown assays, angiomotin (Amot), known to be involved in cell polarity, migration, and Hippo pathway, is identified as a component of the Cad11 protein complex and demonstrated that Amot‐p80 is critical for Cad11‐mediated cell migration.
Cadherin-11 endocytosis through binding to clathrin promotes cadherin-11-mediated migration in prostate cancer cells.
Robert L. Satcher,Tianhong Pan,Mehmet Asim Bilen,Xiaoxia Li,Yu Chen Lee,Angelica Ortiz,Andrew P. Kowalczyk,Li Yuan Yu-Lee,Sue Hwa Lin +8 more
TL;DR: Findings show that recycling of cell adhesion molecules through endocytosis promotes their ability to control cell migration and suggest that dynamic turnover of Cad11 regulates the migratory function of Cad 11 in prostate cancer cells.
Small-molecule protein tyrosine kinase inhibitors for the treatment of metastatic prostate cancer.
TL;DR: Specific protein tyrosine kinases that regulate these complex interactions, including PDGFR, the EGFR family, c-Src, VEGFR, IGF-1R, FGFR and c-Met will be discussed, with an emphasis on why these kinases are promising therapeutic targets for metastatic PCa treatment.