Sudhir Thakurela
Harvard University
21 Papers
76 Citations
Sudhir Thakurela is an academic researcher from Harvard University. The author has contributed to research in topics: Transcription factor & Regulation of gene expression. The author has an hindex of 14, co-authored 20 publications. Previous affiliations of Sudhir Thakurela include Broad Institute & Armenian National Academy of Sciences.
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Papers
Genetic determinants and epigenetic effects of pioneer-factor occupancy
Julie Donaghey,Sudhir Thakurela,Sudhir Thakurela,Jocelyn Charlton,Jennifer S. Chen,Zachary D. Smith,Zachary D. Smith,Hongcang Gu,Ramona Pop,Kendell Clement,Kendell Clement,Elena K. Stamenova,Rahul Karnik,Rahul Karnik,David R. Kelley,Casey A. Gifford,Casey A. Gifford,Davide Cacchiarelli,Davide Cacchiarelli,John L. Rinn,John L. Rinn,John L. Rinn,Andreas Gnirke,Michael J. Ziller,Alexander Meissner,Alexander Meissner,Alexander Meissner +26 more
TL;DR: Investigation ofFOXA2, GATA4 and OCT4 binding across several cell types provides insights into the genetic determinants and epigenetic effects of pioneer-factor occupancy, and suggests that FOXA2 samples most of its potential binding sites but is stabilized at only a subset of targets.
Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state
Vijay K. Tiwari,Lukas Burger,Vassiliki Nikoletopoulou,Rubén Deogracias,Sudhir Thakurela,Christiane Wirbelauer,Johannes Kaut,Rémi Terranova,Leslie Hoerner,Christian Mielke,Fritz Boege,Rabih Murr,Antoine H.F.M. Peters,Yves-Alain Barde,Dirk Schübeler +14 more
TL;DR: A chromatin-based targeting of Top2β to regulatory regions in the genome to govern the transcriptional program associated with neuronal differentiation and longevity is suggested.
Mapping gene regulatory circuitry of Pax6 during neurogenesis
Sudhir Thakurela,Neha Tiwari,Sandra Schick,Angela Garding,Robert Ivanek,Benedikt Berninger,Vijay K. Tiwari +6 more
TL;DR: New aspects of the gene regulatory circuitry of Pax6 are demonstrated, revealing how it functions to control neuronal development at multiple levels to ensure unidirectionality and proper execution of the neurogenic program.
JNK-dependent gene regulatory circuitry governs mesenchymal fate.
Sanjeeb Kumar Sahu,Angela Garding,Neha Tiwari,Sudhir Thakurela,Joern Toedling,Susanne Gebhard,Felipe Ortega,Nikolai Schmarowski,Benedikt Berninger,Robert Nitsch,Marcus Schmidt,Vijay K. Tiwari +11 more
TL;DR: A kinetically distinct role for the JNK pathway is uncovered in defining the transcriptome that underlies mesenchymal identity and novel transcription factors that mediate these responses during development and disease are revealed.
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Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration.
Amrendra Kumar Ajay,Li Fang Zhao,Shruti Vig,Mai Fujiwara,Sudhir Thakurela,Shreyas Jadhav,Andrew Cho,I-Jen Chiu,Yan Ding,Krithika Ramachandran,Arushi Mithal,Aanal Bhatt,Pratyusha Chaluvadi,Manoj Gupta,Sujal I. Shah,Venkata S. Sabbisetti,Ana Maria Waaga-Gasser,David A. Frank,Gopal Murugaiyan,Joseph V. Bonventre,Li Li Hsiao +20 more
TL;DR: In this paper , a previously unknown function of STAT3 was identified in kidney fibrosis and has therapeutic value in fibrosis by using Foxd1-mediated Stat3 knockout mice, CRISPR, and inhibitors of Stat3, which showed that STAT3 activation upregulates the inflammation and differentiates pericytes into myofibroblasts.
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