Sudheer Doss
University of California, Los Angeles
7 Papers
87 Citations
Sudheer Doss is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Quantitative trait locus & Expression quantitative trait loci. The author has an hindex of 7, co-authored 7 publications.
Chat about Author
Papers
Variations in DNA elucidate molecular networks that cause disease
Yanqing Chen,Jun Zhu,Pek Yee Lum,Xia Yang,Shirly Pinto,Douglas J. MacNeil,Chunsheng Zhang,John Lamb,Stephen W. Edwards,Solveig K. Sieberts,Amy Leonardson,Lawrence W. Castellini,Susanna Wang,Marie-France Champy,Bin Zhang,Valur Emilsson,Sudheer Doss,Anatole Ghazalpour,Steve Horvath,Thomas A. Drake,Aldons J. Lusis,Eric E. Schadt +21 more
TL;DR: Application of this method to liver and adipose gene expression data generated from a segregating mouse population results in the identification of a macrophage-enriched network supported as having a causal relationship with disease traits associated with metabolic syndrome.
Integrating Genetic and Network Analysis to Characterize Genes Related to Mouse Weight
Anatole Ghazalpour,Sudheer Doss,Bin Zhang,Susanna Wang,Christopher L. Plaisier,Ruth Castellanos,Alec J. Brozell,Eric E. Schadt,Thomas A. Drake,Aldons J. Lusis,Steve Horvath +10 more
TL;DR: This work uses microarray and genetic marker data from an F2 mouse intercross to examine the large-scale organization of the gene co-expression network in liver, and annotates several gene modules in terms of 22 physiological traits.
Cis-acting expression quantitative trait loci in mice
TL;DR: Cis-acting eQTL serve as an important new resource for the identification of positional candidates in QTL studies in mice and the analysis of the correlation structures between genotypes, gene expression traits, and phenotypic traits is used to further characterize genes expressed in liver that are under cis-acting control.
311
Thematic review series: The pathogenesis of atherosclerosis. Toward a biological network for atherosclerosis.
Anatole Ghazalpour,Sudheer Doss,Xia Yang,Jason E. Aten,Edward M. Toomey,Atila van Nas,Susanna Wang,Thomas A. Drake,Aldons J. Lusis +8 more
TL;DR: This review discusses how the integration of genetics and technologies such as transcriptomics and proteomics, combined with mathematical modeling, may lead to an understanding of networks that influences the development of atherosclerosis.
90
An Integrative Genetics Approach to Identify Candidate Genes Regulating BMD : Combining Linkage, Gene Expression, and Association
Charles R. Farber,Atila van Nas,Anatole Ghazalpour,Jason E. Aten,Sudheer Doss,Brandon C. Sos,Eric E. Schadt,Leslie Ingram-Drake,Richard C. Davis,Steve Horvath,Desmond J. Smith,Thomas A. Drake,Aldons J. Lusis +12 more
TL;DR: An integrative genetics approach, which combines linkage analysis, expression QTL (eQTL) mapping, causality modeling, and genetic association in outbred mice, provides strong support for Wnt9a, Rasd1, or both underlying Bmd11.