Sudesh Kumar
Indian Veterinary Research Institute
14 Papers
54 Citations
Sudesh Kumar is an academic researcher from Indian Veterinary Research Institute. The author has contributed to research in topics: Virus & Recombinant DNA. The author has an hindex of 6, co-authored 14 publications.
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Papers
Velogenic Newcastle Disease Virus as an Oncolytic Virotherapeutics: In Vitro Characterization
Rajiv Kumar,Ashok K. Tiwari,Uttara Chaturvedi,G.V.P.P.S. Ravi Kumar,Aditya Prasad Sahoo,R. S. Rajmani,Lovleen Saxena,Shikha Saxena,Sangeeta Tiwari,Sudesh Kumar +9 more
TL;DR: Newcastle disease virus (NDV), a poultry virus, is nonpathogenic to human and domestic animals and has a long history of being used in oncotherapy research in several preclinical studies, and its cytotoxic potential was evaluated by observing morphological, biochemical, and nuclear landmarks of apoptosis.
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Apoptin as a potential viral gene oncotherapeutic agent.
Prafull Kumar Singh,Ashok K. Tiwari,R. S. Rajmani,G.V.P.P.S. Ravi Kumar,Uttara Chaturvedi,Lovleen Saxena,Shikha Saxena,Juwar Doley,Aditya Prasad Sahoo,Lakshman Santra,Meeta Saxena,Sudesh Kumar,Bhaskar Sharma +12 more
TL;DR: It was found that in VP3-induced apoptosis, caspase-dependent intrinsic pathway plays an important role with the cleavage of poly (ADP-ribose) polymerase (PARP) and there was no evidence of involvement of death receptor-mediated extrinsic pathway.
13
•Journal Article
Characterization and in vitro expression of non-structural 1 protein of canine parvovirus (CPV-2) in mammalian cell line.
Lovleen Saxena,Uttara Chaturvedi,Shikha Saxena,G.V.P.P.S. Ravi Kumar,Anirudha Sahoo,Sudesh Kumar,Juwar Doley,R. S. Rajmani,Prafull Kumar Singh,Rajiv Kumar,Ashok Kumar Tiwari +10 more
TL;DR: This recombinant plasmid may serve as an important tool to evaluate the apoptotic potential of NS-1 protein of canine parvovirus in cultured HeLa cells.
11
Non-Structural protein 1 (NS1) gene of Canine Parvovirus-2 regresses chemically induced skin tumors in Wistar rats.
Lakshman Santra,R. S. Rajmani,G.V.P.P.S. Ravi Kumar,Shikha Saxena,Sujoy K. Dhara,Amit Kumar,Aditya Prasad Sahoo,Lakshya Veer Singh,G. S. Desai,Uttara Chaturvedi,Sudesh Kumar,Ashok K. Tiwari +11 more
TL;DR: It is reported that CPV2.NS1 has no toxic side effects on healthy cells but regresses skin tumors in Wistar rats and can be a possible therapeutic candidate as an alternative to chemotherapy for the treatment of cancer.
11
•Journal Article
Development and in vitro characterization of a bivalent DNA containing HN and F genes of velogenic Newcastle disease virus.
Uttara Chaturvedi,Shahina Kalim,G. S. Desai,Barkha Ratta,Rajiv Kumar,P.V. Ravindra,Sudesh Kumar,B B Dash,Sangeeta Tiwari,Anirudha Sahoo,Ashok Kumar Tiwari +10 more
TL;DR: HN and F genes of velogenic (virulent) strain were amplified and cloned at multiple cloning sites A and B, respectively into pIRES bicistronic vector for use as bivalent DNA vaccine against ND.