Subreena Simrick
King's College London
11 Papers
62 Citations
Subreena Simrick is an academic researcher from King's College London. The author has contributed to research in topics: Caveolin 3 & Cardiac pacemaker. The author has an hindex of 8, co-authored 11 publications. Previous affiliations of Subreena Simrick include National Institutes of Health & Imperial College London.
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Papers
POPDC1S201F causes muscular dystrophy and arrhythmia by affecting protein trafficking
Roland F.R. Schindler,C. Scotton,Jianguo Zhang,Chiara Passarelli,Beatriz Ortiz-Bonnin,Subreena Simrick,Thorsten Schwerte,Kar Lai Poon,Mingyan Fang,Susanne Rinné,Alexander Froese,Viacheslav O. Nikolaev,Christiane Grunert,Thomas Müller,Giorgio Tasca,Padmini Sarathchandra,Fabrizio Drago,Bruno Dallapiccola,Claudio Rapezzi,Eloisa Arbustini,Francesca Romana Di Raimo,Marcella Neri,Rita Selvatici,Francesca Gualandi,Fabiana Fattori,Antonello Pietrangelo,Wenyan Li,Hui Jiang,Xun Xu,Enrico Bertini,Niels Decher,Jun Wang,Thomas Brand,Alessandra Ferlini +33 more
TL;DR: POPDC1 is identified as a disease gene causing a very rare autosomal recessive cardiac arrhythmia and limb-girdle muscular dystrophy, expanding the genetic causes of this heterogeneous group of inherited rare diseases.
The Popeye domain containing genes: essential elements in heart rate control.
TL;DR: The study of the molecular basis of the stress-induced bradycardia in Popdc mice will shed new light on the etiology of pacemaker disease.
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The cAMP-binding Popdc proteins have a redundant function in the heart
TL;DR: A family of membrane-bound cAMP-binding proteins has been identified, which modulate the subcellular localization of effector proteins involved in organizing signalling complexes and assuring proper membrane physiology of cardiac myocytes.
Sprouty genes are essential for the normal development of epibranchial ganglia in the mouse embryo
TL;DR: Reducing the Fgf8 gene dosage only partially rescued defects in the glossopharyngeal nerve and was not sufficient to rescue facial nerve defects, suggesting that FGF8 is functionally redundant with other RTK ligands during facial nerve development.
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The Popeye Domain Containing Genes and cAMP Signaling.
TL;DR: The identification of the two-pore channel TREK-1 and Caveolin 3 as Popdc-interacting proteins represents a first step into understanding the mechanisms of heart rate modulation triggered by Popdc proteins.