Subham Basu
Memorial Sloan Kettering Cancer Center
12 Papers
Subham Basu is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Biology & Cancer research. The author has an hindex of 4, co-authored 4 publications.
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Papers
BAD Enables Ceramide to Signal Apoptosis via Ras and Raf-1
TL;DR: Ceramide signaled apoptosis in BAD-expressing cells by a pathway involving sequentially kinase suppressor of Ras (KSR)/ceramide-activated protein kinase, Ras, c-Raf-1, and MEK1 and the availability of a single target, BAD, may dictate an apoptotic outcome.
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Negative Feedback Loop Mechanism between EAF1/2 and DBC1 in Regulating ELL Stability and Functions
Subham Basu,Arijit Nandy,Mahesh K Barad,S. Pal,Debabrata Biswas +4 more
TL;DR: Coordinated functions of multiple factors, including EAF1/2, HDAC3, DBC1, and TRIM28 in regulating ELL protein level for optimal target gene expression in a context-dependent manner within mammalian cells are described.
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Single-cell Spatial Metabolic and Immune Phenotyping of Head and Neck Cancer Tissues Identifies Tissue Signatures of Response and Resistance to Immunotherapy
Niyati Jhaveri,Bassem Ben Cheikh,Nadya Nikulina,Ning Ma,Dmytro Klymyshyn,James DeRosa,Ritu Mihani,A. Pratapa,Yasmin Kassim,O. Shang,Yan He,Yi Zheng,James Monkman,Caroline Cooper,Kenneth J. O'Byrne,Bhaskar Anand,Michael Prater,Subham Basu,Brett G.M. Hughes,Arutha Kulasinghe,Oliver Braubach +20 more
TL;DR: In this article , the authors applied an ultra-high plex, single-cell spatial protein analysis in head and neck squamous cell carcinomas (HNSCC) to reveal a high degree of intra-tumoral heterogeneity intrinsic to HNSCC and provided unique insights into the biology of the tumor.
Abstract 6774: The development of a spatial metabolic map of immunotherapy sensitive and resistant cutaneous skin carcinoma
Niyati Jhaveri,Dmytro Klymyshyn,Bassem Ben Cheikh,James Monkman,Dan Winkowski,James Mansfield,Subham Basu,Michael Prater,Gabrielle T. Belz,Oliver Braubach,Arutha Kulasinghe +10 more
TL;DR: Jhaveri et al. as discussed by the authors designed a high-dimensional > 50-plex antibody panel identifying cell lineages, activation states, and immune checkpoints, and deployed a combination of antibodies for a multiplexed metabolic readout, to enhance their in situ profiling beyond well-known TME targets.
Abstract 5648: Single cell spatial phenotyping of bladder tumors with a novel mechanism of NKG2A and HLA-E mediated resistance to BCG immunotherapy
Dmytro Klymyshyn,Niyati Jhaveri,Nadine Nelson,Michael Prater,Zhenqin Wu,Steven Hamel,Matthew D. Galsky,Nina Bhardwaj,John P. Sfakianos,Subham Basu,Oliver Braubach,Amir Horowitz +11 more
TL;DR: Klymyshyn et al. as discussed by the authors applied single cell spatial phenotyping to study major subsets of NK cells in the TME of bladder tumors obtained from patient matched tumor sections before and after BCG therapy.