Stuart Taylor
Pfizer
3 Papers
17 Citations
Stuart Taylor is an academic researcher from Pfizer. The author has contributed to research in topics: Stereocenter & Chemistry. The author has an hindex of 3, co-authored 3 publications.
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Papers
Synthesis of Filibuvir. Part I. Diastereoselective Preparation of a β-Hydroxy Alkynyl Oxazolidinone and Conversion to a 6,6-Disubstituted 2H-Pyranone
Robert A. Singer,John A. Ragan,Paul Bowles,Esmort Chisowa,Brian G. Conway,Eric M. Cordi,Kyle R. Leeman,Leo Joseph Letendre,Janice E. Sieser,Gregory W. Sluggett,Corey L. Stanchina,Holly Strohmeyer,Jon Blunt,Stuart Taylor,Ciaran Byrne,Denis Lynch,Sandra Mullane,Maria M. O’Sullivan,Marcella Whelan +18 more
TL;DR: In this article, the first in a series of three papers describing the identification and development of a commercial synthesis of filibuvir (1) was described, where the Evans aldol reaction was used to control the tertiary alcohol stereocenter, a challenging variant of that strategy in that both reacting partners were nonstandard (acetate enolate and ketone electrophile).
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Synthesis of Filibuvir. Part III. Development of a Process for the Reductive Coupling of an Aldehyde and a β-Keto-lactone
Nathan D. Ide,John A. Ragan,Gabriel Bellavance,Steve J. Brenek,Eric M. Cordi,Grace O. Jensen,Kris N. Jones,Danny Lafrance,Kyle R. Leeman,Leo Joseph Letendre,David Place,Corey L. Stanchina,Gregory W. Sluggett,Holly Strohmeyer,Jon Blunt,Kevin Meldrum,Stuart Taylor,Ciaran Byrne,Denis Lynch,Sandra Mullane,Maria M. O’Sullivan,Marcella Whelan +21 more
TL;DR: In this article, a reductive coupling of a β-keto-lactone and an aldehyde is described, in which the Hantzsch ester serves as an inexpensive and convenient reducing agent.
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Synthesis of Filibuvir. Part II. Second-Generation Synthesis of a 6,6-Disubstituted 2H-Pyranone via Dieckmann Cyclization of a β-Acetoxy Ester
Zhihui Peng,John A. Ragan,Roberto Colon-Cruz,Brian G. Conway,Eric M. Cordi,Kyle R. Leeman,Leo Joseph Letendre,Li-Jen Ping,Janice E. Sieser,Robert A. Singer,Gregory W. Sluggett,Holly Strohmeyer,Brian C. Vanderplas,Jon Blunt,Nicola Mawby,Kevin Meldrum,Stuart Taylor +16 more
TL;DR: In this article, an improved sequence for the conversion of an oxazolidinone to a β-keto lactone was described, with the primary drivers behind this change were the modest and variable yields observed in the intramolecular cyclization.
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