Stuart Macaulay
7 Papers
6 Citations
Stuart Macaulay is an academic researcher. The author has contributed to research in topics: Liposome & Chemistry. The author has an hindex of 5, co-authored 7 publications.
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Papers
Preparation of nanoliposomes by microfluidic mixing in herring-bone channel and the role of membrane fluidity in liposomes formation
Jan Kotouček,František Hubatka,Josef Mašek,Pavel Kulich,Kamila Velínská,Jaroslava Bezděková,Martina Fojtíková,Eliška Bartheldyová,Andrea Tomečková,Jana Stráská,D. Hrebik,Stuart Macaulay,Irena Kratochvílová,Milan Raska,Jaroslav Turánek +14 more
TL;DR: The role of phospholipid bilayer fragment as the key intermediate in the mechanism of liposome formation by microfluidic mixing in the channel with “herring-bone” geometry used with the instrument NanoAssemblr is demonstrated.
Hyaluronic Acid Surface Modified Liposomes Prepared via Orthogonal Aminoxy Coupling: Synthesis of Nontoxic Aminoxylipids Based on Symmetrically α-Branched Fatty Acids, Preparation of Liposomes by Microfluidic Mixing, and Targeting to Cancer Cells Expressing CD44.
Eliška Bartheldyová,Roman Effenberg,Josef Mašek,Lubomir Prochazka,Pavlína Turánek Knotigová,Pavel Kulich,František Hubatka,Kamila Velínská,Jaroslava Zelníčková,Darina Zouharová,Martina Fojtíková,D. Hrebik,Pavel Plevka,Robert Mikulik,Andrew D. Miller,Stuart Macaulay,Daniel Zyka,Ladislav Drož,Milan Raska,Miroslav Ledvina,Jaroslav Turánek +20 more
TL;DR: These hyaluronic acid-liposomes represent a potentially new drug delivery platform for CD44-targeted anticancer drugs as well as for immunotherapeutics and vaccines.
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Gadolinium labelled nanoliposomes as the platform for MRI theranostics: in vitro safety study in liver cells and macrophages
Pavlína Šimečková,František Hubatka,Jan Kotouček,Pavlína Turánek Knotigová,Josef Mašek,Josef Slavík,Ondrej Kováč,Jiří Neča,Pavel Kulich,D. Hrebik,Jana Stráská,Kateřina Pěnčíková,Jiřina Procházková,Pavel Diviš,Stuart Macaulay,Robert Mikulik,Milan Raska,Miroslav Machala,Jaroslav Turánek +18 more
TL;DR: Gadolinium (Gd)-based contrast agents are extensively used for magnetic resonance imaging (MRI), and they are potential nanocarrier-based biocompatible platforms for development of new generations of MRI diagnostics.
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N-Oxy lipid-based click chemistry for orthogonal coupling of mannan onto nanoliposomes prepared by microfluidic mixing: Synthesis of lipids, characterisation of mannan-coated nanoliposomes and in vitro stimulation of dendritic cells
Eliška Bartheldyová,Pavlína Turánek Knotigová,Kateřina Zachová,Josef Mašek,Pavel Kulich,Roman Effenberg,Daniel Zyka,František Hubatka,Jan Kotouček,Hana Čelechovská,Renata Héžová,Andrea Tomečková,Eliška Mašková,Martina Fojtíková,Stuart Macaulay,Peter Bystrický,Lucia Paulovičová,Ema Paulovičová,Ladislav Drož,Miroslav Ledvina,Milan Raska,Jaroslav Turánek +21 more
TL;DR: The platform based on mannans bound orthogonally onto the surface of nanoliposomes represents a self-adjuvanted carrier for construction of liposome-based recombinant vaccines for both systemic and mucosal routes of administration.
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Application of Advanced Microscopic Methods to Study the Interaction of Carboxylated Fluorescent Nanodiamonds with Membrane Structures in THP-1 Cells: Activation of Inflammasome NLRP3 as the Result of Lysosome Destabilization
Pavlína Turánek Knotigová,Josef Mašek,František Hubatka,Jan Kotouček,Pavel Kulich,Pavlína Šimečková,Eliška Bartheldyová,Miroslav Machala,Tereza Svadlakova,Jan Krejsek,Naděžda Vaškovicová,Radim Skoupý,Vladislav Krzyžánek,Stuart Macaulay,Michael Katzuba,Ladislav Fekete,Petr Ashcheulov,Milan Raska,Irena Kratochvílová,Jaroslav Turánek +19 more
TL;DR: This is the first in vitro study demonstrating direct activation of inflammasome by ND, important for understanding the mechanism(s) of action of ND complexes and explain the ambiguity of the existing toxicological data.
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