9 Papers
1 Citations
Stuart Hay is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Gene & Biology. The author has an hindex of 4, co-authored 6 publications.
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Papers
cellHarmony: cell-level matching and holistic comparison of single-cell transcriptomes
Erica A K DePasquale,Erica A K DePasquale,Daniel Schnell,Phillip Dexheimer,Phillip Dexheimer,Kyle Ferchen,Kyle Ferchen,Stuart Hay,Kashish Chetal,Iñigo Valiente-Alandi,Burns C. Blaxall,Burns C. Blaxall,H. Leighton Grimes,Nathan Salomonis,Nathan Salomonis +14 more
TL;DR: It is demonstrated that cellHarmony has improved or equivalent performance to alternative label projection methods, is able to identify the likely cellular origins of malignant states, stratify patients into clinical disease subtypes from identified gene programs, resolve discrete disease networks impacting specific cell-types, and illuminate therapeutic mechanisms.
An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors.
Xuan Zhang,MJ Carlino,Guangyuan Li,Kyle Ferchen,Mi Chen,Evrett N. Thompson,Bailee N Kain,Dan Schnell,Kairavee Thakkar,Michal Kouril,Kang Jin,Stuart Hay,Sidharth Sen,David Bernardicius,Siyuan Ma,Sierra Bennett,Josh Croteau,O. Salvatori,Melvin H Lye,Austin Gillen,Craig T. Jordan,Harinder Singh,Diane S Krause,Nathan A. Salomonis,H. L. Grimes +24 more
TL;DR: Researchers created a comprehensive atlas of human hematopoietic progenitors using CITE-seq, identifying over 80 distinct cell types and surface markers, and nominating normal marrow equivalents for acute myeloid leukemia stem cells.
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cellHarmony: Cell-level matching and comparison of single-cell transcriptomes
Erica A K DePasquale,Erica A K DePasquale,Kyle Ferchen,Kyle Ferchen,Stuart Hay,David E. Muench,H. Leighton Grimes,Nathan Salomonis,Nathan Salomonis +8 more
TL;DR: In this article, a new computational approach called cellHarmony is presented to consistently classify individual cells from a query (i.e., mutant) against a reference (i., wild-type) dataset to discover crucial differences in discrete or transitional cell-populations.
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Abstract 3139: Pan-cancer splicing analysis reveals shared drivers of malignant transformation and survival
Anukana Bhattacharjee,Audrey Crowther,Guangyuan Li,Meenakshi Venkatasubramanian,Daniel Schnell,Stuart Hay,Krithika Subramanian,Kashish Chetal,Xiaoting Chen,Aishwarya Kulkarni,Matthew T. Weirauch,Nathan Salomonis +11 more
TL;DR: Bhattacharjee et al. as mentioned in this paper identified common and malignancy specific splicing subtypes across cancer using genome variant data from RNA-Seq in conjunction with fully unsupervised analyses (NMF and SVM) to identify novel patient splicing-defined subtypes.
Developmental dynamics and genomic programming of GC-derived precursors that give rise to long lived plasma cells
Godhev Kumar Manakkat Vijay,Kairavee Thakkar,Kashish Chetal,Stuart Hay,Jingyu Fan,Alok V. Joglekar,Nathan Salomonis,Harinder Singh +7 more
TL;DR: In this paper, the developmental dynamics and genomic states of PC precursors were elucidated at single-cell resolution using a novel experimental system, involving CD138+ splenocytes isolated from NP-KLH immunized C57Bl/6J mice and their adoptive transfer into B cell deficient mMT mice.