Stuart Brabbs
University of Michigan
8 Papers
7 Citations
Stuart Brabbs is an academic researcher from University of Michigan. The author has contributed to research in topics: Innate immune system & T cell. The author has an hindex of 4, co-authored 8 publications.
Chat about Author
Papers
Microbial metabolite sensor GPR43 controls severity of experimental GVHD.
Hideaki Fujiwara,Melissa D. Docampo,Mary Riwes,Daniel Peltier,Tomomi Toubai,Israel Henig,S. Julia Wu,Stephanie Kim,Austin Taylor,Stuart Brabbs,Chen Liu,Cynthia Zajac,Katherine Oravecz-Wilson,Yaping Sun,Gabriel Núñez,John E. Levine,Marcel R.M. van den Brink,James L.M. Ferrara,Pavan Reddy +18 more
TL;DR: The metabolite sensor G-protein-coupled receptor 43 (GPR43) is important for attenuation of gastrointestinal GVHD in multiple clinically relevant murine models and is required for controlling disease pathology severity in the context of experimental models of GV HD.
Host NLRP6 exacerbates graft-versus-host disease independent of gut microbial composition.
Tomomi Toubai,Hideaki Fujiwara,Corinne Rossi,Mary Riwes,Hiroya Tamaki,Cynthia Zajac,Chen Liu,Anna V. Mathew,Jaeman Byun,Katherine Oravecz-Wilson,Ikuo Matsuda,Yaping Sun,Daniel Peltier,Julia Wu,Jiachen Chen,Sergey S. Seregin,Israel Henig,Stephanie Kim,Stuart Brabbs,Subramaniam Pennathur,Grace Y. Chen,Pavan Reddy +21 more
TL;DR: An unexpected, pathogenic role for host NLRP6 in gastrointestinal GVHD is unveiled that is independent of variations in the intestinal microbiome and in contrast to its well-appreciated microbiome-dependent protective role in intestinal colitis and tumorigenesis.
39
IAPs protect host target tissues from graft-versus-host disease in mice.
Tomomi Toubai,Corinne Rossi,Katherine Oravecz-Wilson,Chen Liu,Cynthia Zajac,Shin Rong Julia Wu,Yaping Sun,Hideaki Fujiwara,Hiroya Tamaki,Daniel Peltier,Mary Riwes,Israel Henig,Stuart Brabbs,Colin S. Duckett,Shaomeng Wang,Pavan Reddy +15 more
TL;DR: A novel immune cell-independent but target tissue-intrinsic role for IAPs in the regulation of gastrointestinal damage from GVHD is highlighted.
16
NLRP6 in Host Target Tissues Exacerbates Graft-Versus-Host Disease
Tomomi Toubai,Corinne Rossi,Hiroya Tamaki,Nathan Mathewson,Katherine Oravecz-Wilson,Cynthia Zajac,Chen Liu,Stuart Brabbs,Yaping Sun,Grace Y. Chen,Pavan Reddy +10 more
TL;DR: The data collectively demonstrate that the reduction in GI GVHD, observed in the absence of NLRP6, is independent of NOD-like receptor family pyrin domain containing 6 expression in host hematopoietic derived cells.
3