The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.

Methods for treating hepatitis c

Purpose: To investigate the role of a thiol-containing biologically active compound in lipid peroxidation of membranes. Materials and methods: Thiyl radicals were generated from 3-(2-mercaptoethyl)quinazoline-2,4(1H,3H)-dione (MECH) using pulse radiolysis and gamma -radiolysis in aqueous and alcoholic solutions saturated with N2O. The products were analysed by 1H NMR and by HPLC. Results: The thiyl radicals abstract bisallylic hydrogens from {cis-9,cis-12}-methyl linoleate, yielding a pentadienyl radical. In the absence of oxygen, a thiyl radical-induced cis/trans-isomerization leads to linoleic-type isomers. These chain-type isomerization reactions can occur with the long living pentadienyl radical, followed by a 'repair' reaction of the attached thiol, and with the thiyl radical adduct with a double bond of the fatty acid residue. Conclusions: The results show that the mechanism of cis/trans isomerization is an integral part of the thiyl radical attack on polyunsaturated fatty acids in homogeneous solut...

Thiyl radical-induced cis/trans-isomerization of methyl linoleate in methanol and of linoleic acid residues in liposomes.

The aim of the invention is the discovery and investigation of novel chemical entities of a non-proteinogenic structure which have a matrix-metalloproteinase(MMP)-inhibiting effect. Said aim is achieved by means of the synthesis of dimercaptoalkyl-substituted quinazolin-2,4(1H,3H)-diones. Compounds of the above substance class display an unexpectedly clear and hence pharmacologically interesting MMP-inhibiting effect.

New 1-(dimercaptoalkyl)-quinazoline-2,4(1H,3H)-diones, are stable matrix metalloproteinase inhibitors useful e.g. for treating rheumatism, tumor metastasis or sunburn

Polycyclic pyrimidine-2,4(1H, 3H)-dione having functionalized alkyl radicals in 1-and/or 3-position; method for its preparation and pharmaceutical preparations therefrom; the aim of the invention is to produce and characterize the title compounds and determine their physiological activity. That aim is achieved by providing synthesis pathways, by producing the substances and by providing the specific characteristics of the substance. In pharmaceutical preparations, the substances produced develop a remarkable collagen-inhibiting effect. 1-(3-mercaptoprop-1-yl)-3-methxl-chinazoline-2,4(1H, 3H)-dione is cited as an example.

Polycyclic pyrimidine-2,4(1h, 3h)-dione with functionalized alkyl radicals in 1- and/or 3-position, method for the production thereof and pharmaceutical preparations

Mercaptomethyl-substituted thiazolo (2,3-b) quinazolinone, oxazolo (2,3-b) quinazolinone, imidazo (2,1-b) quinazolinone or benzothiadiazoline-5,5-dioxide derivatives (I) or (II), their tautomers or salts, are new. Mercaptomethyl-substituted thiazolo (2,3-b) quinazolinone, oxazolo (2,3-b) quinazolinone, imidazo (2,1-b) quinazolinone or benzothiadiazoline-5,5-dioxide derivatives of formula (I) or (II), their tautomers or salts, are new. R1 = H, Me, OMe, (OMe)2, F, Cl, Br or COOH; R2-R4 = H or Me; X = CO or SO2; and Y = S, O or NH. An Independent claim is included for the preparation of (I) and (II).

New mercaptomethyl-substituted tricyclic quinazolinone derivatives, are matrix metalloprotease inhibitors useful for treating cancer, rheumatism, inflammatory reactions or allergies

of EP0454060The invention relates to 3-(mercaptoalkyl) quinazoline-2,4(1H,3H)-diones of the formula I in which: R denotes hydrogen, 6-methyl, 6-fluoro, 6-chloro, 6-bromo or 6,7-dimethoxy, R denotes hydrogen or methyl and n denotes 1 or 2, including their salts and tautomers, a process for their preparation and their use in pharmaceutical compositions. The compounds of the formula I are distinguished by advantageous immunostimulating or immunorestorative and antiviral activity, so that they can be employed favourably in human and veterinary medicine for the treatment of immune diseases and virus infections.

3- (Mercaptoalkyl) quinazoline-2,4 (1H, 3H) -dione, processes for their preparation and pharmaceutical preparations

Verfahren zur herstellung von 3-(alkylthioalkyl)-2,4-dioxo-1,2,3,4-tetrahydro-chinazolinen

Verfahren zur herstellung von (2,4-dioxo-1,2,3,4-tetrahydro-chinazolin-3-yl)-alkylthioalkansaeuren und deren alkylestern

Verfahren zur herstellung von gegebenenfalls in 7,8- bzw. 8,9-stellung cycloaliphatisch verbrueckten 4-oxo-3,4-dihydro-pyrido/3',2':4,5/thieno/3,2-d/pyrimidin-2-carbonsaeuren

Verfahren zur herstellung von 8,9,10,11-tetrahydro-pyrimido/4',5':4,5/thieno/2,3-c/isochinolin-4(3h)-onen und 7,8,9,10-tetrahydro-pyrimido/4',5':4,5/thieno/2,3-b/chinolin-4(3h)-onen jeweils mit einem (funktionalisierten) alkylrest in 3-position

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