Steven V. John
Morgridge Institute for Research
11 Papers
Steven V. John is an academic researcher from Morgridge Institute for Research. The author has contributed to research in topics: Chemistry & Pyruvate dehydrogenase complex. The author has an hindex of 3, co-authored 4 publications. Previous affiliations of Steven V. John include University of Wisconsin-Madison.
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Papers
Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-γ stimulation.
Gretchen L. Seim,Gretchen L. Seim,Emily C. Britt,Emily C. Britt,Steven V. John,Steven V. John,Franklin J. Yeo,Aaron R. Johnson,Richard S. Eisenstein,Richard S. Eisenstein,David J. Pagliarini,David J. Pagliarini,Jing Fan,Jing Fan +13 more
- 01 Jul 2019
TL;DR: This study elucidates a dynamic and mechanistic picture of metabolic reprogramming in LPS and interferon-γ stimulated macrophages, and provides insights into how changing metabolism can regulate the functional transitions in macrophage over a course of immune response.
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Metabolic regulation of epigenetic remodeling in immune cells
TL;DR: Recent studies are reviewed that demonstrate shifts in metabolic state can orchestrate immune cell functions through its impact on epigenetic remodeling, and the microenvironment can exert its influence on immune cells through the metabolic regulation of epigenetics.
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Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases
TL;DR: In this paper , reactive nitrogen species (RNS) can covalently modify the thiols on their lipoic arms, generating a series of adducts that block catalytic activity.
Metabolomic and Lipidomic Analysis of Bone Marrow Derived Macrophages
Gretchen L. Seim,Gretchen L. Seim,Steven V. John,Jing Fan,Jing Fan +4 more
- 20 Jul 2020
TL;DR: This method simultaneously extracts polar metabolites and lipids from BMDMs using a rapid two-phase extraction procedure and allows for a comprehensive characterization of cellular metabolism that can be used to understand the impact of a variety of environmental stimuli on macrophage metabolism and function.
Haem biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue.
Dylan J. Duerre,Julia K. Hansen,Steven V. John,Annie Jen,Noah D. Carrillo,Hoang Bui,Yutong Bao,Matias Fabregat,J. Leon Catrow,Li‐Yu Chen,Katherine A. Overmyer,Evgenia Shishkova,Quentinn Pearce,Mark P. Keller,Richard A. Anderson,Vincent L. Cryns,Allan Attie,James E. Cox,Joshua J. Coon,Jing Fan,A. Galmozzi +20 more
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