Steven Langer
University of Alberta
4 Papers
Steven Langer is an academic researcher from University of Alberta. The author has contributed to research in topics: Fragile X syndrome & Offspring. The author has an hindex of 4, co-authored 4 publications.
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Papers
Insulin signaling is acutely required for long-term memory in Drosophila
Daniel B. Chambers,Alaura Androschuk,Cory Rosenfelt,Steven Langer,Mark Harding,Francois V. Bolduc +5 more
TL;DR: It is found that insulin signaling (InS) is involved in both learning and memory in Drosophila and that InS is acutely required for long-term memory formation in adult flies.
Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models
Catherine H. Choi,Catherine H. Choi,Catherine H. Choi,Brian P. Schoenfeld,Brian P. Schoenfeld,Aaron J. Bell,Aaron J. Bell,Joseph Hinchey,Cory Rosenfelt,Michael Gertner,Sean Campbell,Danielle Emerson,Paul Hinchey,Maria Kollaros,Neal J. Ferrick,Neal J. Ferrick,Daniel B. Chambers,Steven Langer,Steven Sust,Aatika Malik,Allison M. Terlizzi,David A. Liebelt,David Ferreiro,Ali Sharma,Eric Koenigsberg,Richard J. Choi,Natalia Louneva,Steven E. Arnold,Robert E. Featherstone,Steven J. Siegel,R. Suzanne Zukin,Thomas V. McDonald,Francois V. Bolduc,Thomas A. Jongens,Sean M.J. McBride,Sean M.J. McBride +35 more
TL;DR: It is demonstrated that the same three strategies used previously with the potential to be used clinically, lithium treatment, PDE-4 inhibitor treatment or mGluR antagonist treatment can rescue long term memory in the fly model and alter the cAMP signaling pathway in the hippocampus of the mouse model.
Cognitive Enhancement in Infants Associated with Increased Maternal Fruit Intake During Pregnancy: Results from a Birth Cohort Study with Validation in an Animal Model
Francois V. Bolduc,Amanda Lau,Cory Rosenfelt,Steven Langer,Nan Wang,Lisa Smithson,Diana L. Lefebvre,R. Todd Alexander,Clayton T. Dickson,Liang Li,Allan B. Becker,Padmaja Subbarao,Stuart E. Turvey,Jacqueline Pei,Malcolm R. Sears,Piush J. Mandhane +15 more
TL;DR: This study supports increased fruit consumption during pregnancy with significant increases in infant cognitive performance, and shows that the cyclic adenylate monophosphate (cAMP) pathway may be a major regulator of this effect.
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Insulin signaling misregulation underlies circadian and cognitive deficits in a Drosophila fragile X model.
Rachel E. Monyak,Danielle Emerson,Brian P. Schoenfeld,Brian P. Schoenfeld,Xiangzhong Zheng,Daniel B. Chambers,Cory Rosenfelt,Steven Langer,Paul Hinchey,Catherine H. Choi,Catherine H. Choi,Thomas V. McDonald,Francois V. Bolduc,Amita Sehgal,Sean M.J. McBride,Thomas A. Jongens +15 more
TL;DR: The results indicate that insulin misregulation underlies the circadian and cognitive phenotypes displayed by the Drosophila fragile X model, and thus reveal a metabolic pathway that can be targeted by new and already approved drugs to treat fragile X patients.