Steven J. Stout
Novartis
12 Papers
193 Citations
Steven J. Stout is an academic researcher from Novartis. The author has contributed to research in topics: Liquid chromatography–mass spectrometry & Tandem mass spectrometry. The author has an hindex of 9, co-authored 12 publications. Previous affiliations of Steven J. Stout include Merck & Co..
Chat about Author
Papers
Absorption, tissue distribution, metabolism, and excretion of moxidectin in cattle
TL;DR: In this article, the absorption, tissue distribution, metabolism, and excretion of moxidectin, a new endectocide for the control of internal and external parasites in cattle and sheep, was studied in cattle.
90
Mass spectrometric techniques for label-free high-throughput screening in drug discovery.
Thomas P. Roddy,Christopher Horvath,Steven J. Stout,Kristin L. Kenney,Pei-I Ho,Ji-Hu Zhang,Chad Vickers,Virendar K. Kaushik,Brian K. Hubbard,Y. Karen Wang +9 more
TL;DR: Three techniques that have been adapted for large-scale compound library screening, including four-way parallel multiplexed electrospray liquid chromatography tandem mass spectrometry (MUX-LC/MS/MS), four- way parallel staggered gradient liquid Chromatography tandem Mass Spectrometry(MS/ MS), and eight-way staggered flow injection MS/MS following 384-well plate solid-phase extraction (SPE), are described.
83
Photolysis of imazapyr (AC 243997) herbicide in aqueous media
TL;DR: In this paper, photodegradation of imazapyr 14 C labeled at the carboxyl and 5-oxocarbon positions was carried out separately under borosilicate-filtered xenon arc light at 25 °C in aqueous media.
43
Moxidectin: absorption, tissue distribution, excretion, and biotransformation of 14C-labeled moxidectin in sheep.
TL;DR: In this paper, the absorption, tissue distribution, excretion, and biotransformation of moxidectin, a novel endectocide that combats internal and external parasites in sheep, cattle, and horse, were studied in sheep.
43
Discovery of Novel Allosteric Non‐Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding
Andreas Marzinzik,René Amstutz,Guido Bold,E. Bourgier,Simona Cotesta,J. Fraser Glickman,J. Fraser Glickman,Marjo Götte,Christelle Henry,S. Lehmann,J. Constanze D. Hartwieg,Silvio Ofner,Xavier Pelle,Thomas P. Roddy,Jean-Michel Rondeau,Frédéric Stauffer,Steven J. Stout,Steven J. Stout,Armin Widmer,Johann Zimmermann,Thomas Zoller,Wolfgang Jahnke +21 more
TL;DR: Two new chemical classes of allosteric FPPS inhibitors that belong to the salicylic acid and quinoline chemotypes are found, by an integrated lead finding approach, and are devoid of any affinity for bone mineral and could serve as leads to evaluate their potential in none‐bone diseases.
29