Steven Goldstein

TL;DR: An acellular, unfixed porcine aortic valve-based construct has been engineered to achieve the equivalent of an autograft, and short-term durability of these novel implants demonstrates for the first time the possibility of an engineered Autograft.

TL;DR: In this paper, a method for generating functional hybrid bioprosthesis is described, in which a tissue formed naturally of interstitial collagens is treated to kill native cells and remove potentially immunologically active soluble molecules, and then it may be treated sequentially with extracellular matrix adhesion factor such as fibronectin, extacellular matrix glycosaminoglycan such as heparin, and growth factor appropriate to the cell type required to function within the matrix, and incubating the transplant tissue matrix with cells that are either allogeneic or autolog

TL;DR: Overall, this study indicates that the conventional cryopreservation of human heart valve allografts does not detrimentally affect their collagen and elastin structural integrity.

TL;DR: A closed, sterile pulsatile flow loop for studying tissue valves is presented in this paper, which exposes viable tissue valves to a dynamic flow environment imitating that of the aortic valve.