Steven E. Finkel
University of California, Los Angeles
3 Papers
Steven E. Finkel is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Factor For Inversion Stimulation Protein & DNA. The author has an hindex of 3, co-authored 3 publications.
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Papers
The molecular structure of wild-type and a mutant Fis protein: relationship between mutational changes and recombinational enhancer function or DNA binding.
Hanna S. Yuan,Steven E. Finkel,Jin-An Feng,Maria Kaczor-Grzeskowiak,Reid C. Johnson,Richard E. Dickerson +5 more
TL;DR: The proposed complex explains the experimentally observed patterns of methylation protection and DNase I cleavage hypersensitivity, and accounts for the effects of mutations in the Fis sequence.
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Variable Structures of Fis-DNA Complexes Determined by Flanking DNA – Protein Contacts
TL;DR: Analysis of DNA scission by a collection of Fis conjugates to 1,10-phenanthroline-copper combined with comparative gel electrophoresis has shown that the structures of F is-DNA complexes are highly variable, displaying overall DNA curvatures that range from < or = 50 degrees to > or = 90 degrees.
Structure of the Escherichia coli Fis-DNA complex probed by protein conjugated with 1,10-phenanthroline copper(I) complex
TL;DR: The scission patterns obtained on four different Fis binding sites indicate that Fis positions itself on these highly divergent DNA sequences in a very similar fashion, and patterns of cleavage generally support a model of a Fis-DNA complex that contains specific bends within the core-recognition sequence.