8 Papers
16 Citations
Steve Leonard is an academic researcher from National Institute for Occupational Safety and Health. The author has contributed to research in topics: Chemistry & Dissociation (chemistry). The author has an hindex of 7, co-authored 8 publications.
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Papers
Raw Single-Wall Carbon Nanotubes Induce Oxidative Stress and Activate MAPKs, AP-1, NF-κB, and Akt in Normal and Malignant Human Mesothelial Cells
Maricica Pacurari,Xuejun J. Yin,Jinshun Zhao,Ming Ding,Steve Leonard,Diane Schwegler-Berry,Barbara S. Ducatman,Deborah Sbarra,Mark D. Hoover,Vincent Castranova,Val Vallyathan +10 more
TL;DR: The cellular and molecular findings reported here suggest that SWCNTs can cause potentially adverse cellular responses in mesothelial cells through activation of molecular signaling associated with oxidative stress, which is of sufficient significance to warrant in vivo animal exposure studies.
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Perfluorooctane sulfonate (PFOS) induces reactive oxygen species (ROS) production in human microvascular endothelial cells: role in endothelial permeability
Yong Qian,Alan M. Ducatman,Rebecca Ward,Steve Leonard,Valerie C. Bukowski,Nancy Lan Guo,Xianglin Shi,Val Vallyathan,Vincent Castranova +8 more
TL;DR: Data demonstrated that exposure of human microvascular endothelial cells (HMVEC) to PFOS induced the production of reactive oxygen species (ROS) at both high and low concentrations, and indicated that the generation of ROS may play a role in PFOS-induced aberrations of the endothelial permeability barrier.
163
Reactivity of Free Radicals on Hydroxylated Quartz Surface and Its Implications for Pathogenicity of Silicas: Experimental and Quantum Mechanical Study
TL;DR: In this article, the authors studied the adsorption of hydroxyl radicals and superoxide anion radicals on an alpha-quartz surface using cluster and periodic slab models by means of density functional calculations.
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The role of nodose ganglia in the regulation of cardiovascular function following pulmonary exposure to ultrafine titanium dioxide.
Hong Kan,Zhongxin Wu,Yen-Chang Lin,Teh-hsun Chen,Jared L. Cumpston,Michael L. Kashon,Steve Leonard,Albert E. Munson,Vincent Castranova +8 more
TL;DR: The authors demonstrated that pulmonary exposure of rats to ultrafine titanium dioxide (UFTiO2) significantly increased heart rate and depressed diastolic function of the heart in response to isoproterenol, and the effects of pulmonary inhalation of UFTi O2 on cardiovascular function are most likely triggered by a lung-nodose ganglia-regulated pathway via the activation of TRP channels in the lung.
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Comparative in Vitro Toxicity of Grape- and Citrus-Farm Dusts*
TL;DR: Crystalline silica used in these studies was more cytotoxic than grape- and citrus-farm dusts, however, in general, citrus farm dust exhibited the greatest ability to generate ROS and induce lipid peroxidation.
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