Steve A. McClain
Montefiore Medical Center
4 Papers
30 Citations
Steve A. McClain is an academic researcher from Montefiore Medical Center. The author has contributed to research in topics: Borrelia burgdorferi & Spirochaetaceae. The author has an hindex of 4, co-authored 4 publications.
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Papers
Impact of Genotypic Variation of Borrelia burgdorferi Sensu Stricto on Kinetics of Dissemination and Severity of Disease in C3H/HeJ Mice
Guiqing Wang,Caroline Ojaimi,Radha Iyer,Victoria Saksenberg,Steve A. McClain,Gary P. Wormser,Ira Schwartz +6 more
TL;DR: Spirochete dissemination and disease severity vary significantly in mice infected with distinct genotypes of B. burgdorferi, suggesting that genotypic differences in the infecting spirochetes play a key role in the pathogenesis and development of clinical disease.
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Impaired host defense to infection and Toll-like receptor 2-independent killing of Borrelia burgdorferi clinical isolates in TLR2-deficient C3H/HeJ mice
TL;DR: The data suggest that there is impaired host innate defense against infection and TLR 2-independent killing of B. burgdorferi clinical isolates in TLR2-deficient C3H/HeJ mice.
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Evaluation of a new liquid occlusive dressing for excisional wounds
TL;DR: It is concluded that excisional wounds treated with the liquid occlusive dressing reepithelialize as quickly as hydrocolloid‐treated wounds and is an effective microbial barrier and hemostatic agent resulting in fewer foreign body reactions than Hydrocolloids treated wounds or controls.
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Disease Severity in a Murine Model of Lyme Borreliosis Is Associated with the Genotype of the Infecting Borrelia burgdorferi Sensu Stricto Strain
Guiqing Wang,Caroline Ojaimi,Hongyan Wu,Victoria Saksenberg,Radha Iyer,Dionysios Liveris,Steve A. McClain,Gary P. Wormser,Ira Schwartz +8 more
TL;DR: The pathogenicity of Borrelia burgdorferi sensu stricto clinical isolates representing 2 distinct ribosomal DNA spacer restriction fragment-length polymorphism genotypes (RSTs) was assessed in a murine model of Lyme disease and the RST1 genotype may represent a recently evolved clonal lineage that is highly pathogenic in humans and animals.