Stephen Tonna
University of Melbourne
19 Papers
177 Citations
Stephen Tonna is an academic researcher from University of Melbourne. The author has contributed to research in topics: Alport syndrome & Osteoblast. The author has an hindex of 14, co-authored 18 publications. Previous affiliations of Stephen Tonna include Harvard University & Baker IDI Heart and Diabetes Institute.
Chat about Author
Papers
Thin basement membrane nephropathy.
TL;DR: Families with TBMN in whom hematuria does not segregate with the COL4A3/COL4A4 locus can be explained by de novo mutations, incomplete penetrance of hematuría, coincidental hematurIA in family members without COL4 a3 or COL4a4 mutations, and by a novel gene locus for T BMN.
272
A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9
Giulio Genovese,Giulio Genovese,Stephen Tonna,Stephen Tonna,Andrea L. Uscinski Knob,Gerald B. Appel,Avi Katz,Andrea J. Bernhardy,Alexander Needham,Ross Lazarus,Martin R. Pollak,Martin R. Pollak +11 more
TL;DR: A genome-wide association analysis using more than one million single-nucleotide polymorphisms in 56 African-American and 61 European-American patients with biopsy-confirmed FSGS found variants within a 60 kb region of chromosome 22 containing part of the APOL1 and MYH9 genes associated with increased risk of FSGS.
176
EphrinB2/EphB4 inhibition in the osteoblast lineage modifies the anabolic response to parathyroid hormone.
Farzin M. Takyar,Stephen Tonna,Stephen Tonna,Patricia W. M. Ho,Blessing Crimeen-Irwin,Emma Baker,Emma Baker,T. John Martin,T. John Martin,Natalie A. Sims,Natalie A. Sims +10 more
TL;DR: It is indicated that ephrinB2/EphB4 signaling within the osteoblast lineage is required for late stages of osteOBlast differentiation and, further, restricts the ability of osteoblasts to support osteoclast formation, at least in part by limiting RANKL production.
96
EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis
Stephen Tonna,Farzin M. Takyar,Christina Vrahnas,Blessing Crimeen-Irwin,Patricia W. M. Ho,Ingrid J Poulton,Holly J. Brennan,Narelle E. McGregor,E H Allan,Huynh Nguyen,Mark R. Forwood,Liliana Tatarczuch,Eleanor J. Mackie,T. John Martin,Natalie A. Sims +14 more
TL;DR: Osteoblast differentiation and bone strength are maintained by antiapoptotic actions of ephrinB2 signaling within the osteoblast lineage, which promotes bone mineralization by preventing apoptosis.
84
NPHS2 variation in focal and segmental glomerulosclerosis
Stephen Tonna,Alexander Needham,Krishna R. Polu,Andrea L Uscinski,Gerald B. Appel,Ronald J. Falk,Avi Katz,Salah al-Waheeb,Bernard S. Kaplan,George Jerums,Judy Savige,Jennifer Harmon,Kang Zhang,Gary C. Curhan,Martin R. Pollak +14 more
TL;DR: NPHS2 mutations are a rare cause of FSGS in adults and the most common non-synonymous NPHS2 variants do not appear to alter the risk of proteinuria in the general population nor does p.R229Q associate with measures of kidney dysfunction in diabetic individuals.
56