Stephen P. Cavnar
University of Michigan
13 Papers
104 Citations
Stephen P. Cavnar is an academic researcher from University of Michigan. The author has contributed to research in topics: Cancer cell & Metastasis. The author has an hindex of 11, co-authored 13 publications. Previous affiliations of Stephen P. Cavnar include Boston Consulting Group.
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Papers
Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells.
Jonathan W. Song,Stephen P. Cavnar,Ann C. Walker,Kathryn E. Luker,Mudit Gupta,Yi-Chung Tung,Gary D. Luker,Shuichi Takayama +7 more
TL;DR: It is suggested that targeting CXCL12-CXCR4 signaling in endothelium may limit metastases in breast and other cancers and highlight the unique capabilities of the microfluidic device to advance studies of the intravascular microenvironment in metastasis.
CXCL12-γ in primary tumors drives breast cancer metastasis.
Paramita Ray,Amanda C. Stacer,Joseph Fenner,Stephen P. Cavnar,Kaille F. Meguiar,Martha E. Brown,Kathryn E. Luker,Gary D. Luker +7 more
TL;DR: These studies identify CXCL12-γ as a potent pro-metastatic molecule with important implications for cancer biology and effective therapeutic targeting of CXCR4+ breast cancer cells and mammary fibroblasts.
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Endothelial CXCR7 regulates breast cancer metastasis.
Amanda C. Stacer,Joseph Fenner,Stephen P. Cavnar,Annie Xiao,Shuang G. Zhao,S. L. Chang,A Salomonnson,K. E. Luker,Gary D. Luker +8 more
TL;DR: It is established that endothelial CXCR7 limits breast cancer metastasis at multiple steps in the metastatic cascade, advancing understanding of CXCL12 pathways in tumor environments and informing ongoing drug development targeting CX CR7 in cancer.
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Transfer, imaging, and analysis plate for facile handling of 384 hanging drop 3D tissue spheroids.
Stephen P. Cavnar,Emma Salomonsson,Emma Salomonsson,Kathryn E. Luker,Gary D. Luker,Shuichi Takayama,Shuichi Takayama +6 more
TL;DR: The hanging drop spheroid plate and complementary TRIM plate are built on to facilitate analyses of spheroids across the spectrum of throughput, particularly for bulk collection of sp Heroids and high-content imaging.
Microfluidic source-sink model reveals effects of biophysically distinct CXCL12 isoforms in breast cancer chemotaxis
Stephen P. Cavnar,Paramita Ray,Pranav Moudgil,S. L. Chang,Kathryn E. Luker,Jennifer J. Linderman,Shuichi Takayama,Gary D. Luker +7 more
TL;DR: Physiological gradient formation within the device facilitated interrogation of key differences in chemotaxis among CXCL12 isoforms and suggests CXCR12-γ as a biomarker for metastatic cancer.
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