Stephen N. Mitchell
Eli Lilly and Company
37 Papers
607 Citations
Stephen N. Mitchell is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Dopamine & Nucleus accumbens. The author has an hindex of 22, co-authored 37 publications.
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Papers
Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake.
Frank P. Bymaster,E. E. Beedle,Jeremy Findlay,Peter Thaddeus Gallagher,J. H. Krushinski,Stephen N. Mitchell,David W. Robertson,Dennis Charles Thompson,Louise Wallace,David T. Wong +9 more
TL;DR: A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake, and one member, duloxetine, has proven to be effective in clinical trials for the treatment of depression.
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The Rapidly Acting Antidepressant Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Rapidly Engage Dopaminergic Mood Circuits.
Jeffrey M. Witkin,James A. Monn,Darryle D. Schoepp,Xia Li,Carl D Overshiner,Stephen N. Mitchell,Guy Carter,Bryan G. Johnson,Kurt Rasmussen,Linda M. Rorick-Kehn +9 more
TL;DR: In this paper, the effects of acute administration of ketamine and the mGlu2/3 receptor antagonist LY341495 were evaluated in preclinical models using electrophysiologic, neurochemical, and behavioral endpoints.
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Effect of acute administration of nicotine on in vivo release of noradrenaline in the hippocampus of freely moving rats : a dose-response and antagonist study
TL;DR: The results suggest that (-)-nicotine, dose-dependently stimulated the release and metabolism of amine transmitters by an action at central nicotinic receptors, however, the precise site of action requires further elucidation.
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Modulation of dopamine release in the nucleus accumbens by 5-HT1B agonists: involvement of the hippocampo-accumbens pathway
TL;DR: Serotonin interaction with the mesolimbic dopaminergic system involves postjunctional 5-HT1B heteroreceptors located in the ventral subicular area, which modulate the activity of glutamatergic hippocampo-accumbens pathways and only secondarily alter DA levels in the n.
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Effects of chronic and subchronic nicotine on tyrosine hydroxylase activity in noradrenergic and dopaminergic neurones in the rat brain.
TL;DR: It was established that nicotine for 7 days was sufficient to increase the activity of the enzymes to the same extent in the terminals at 21 days even without further nicotine administration, consistent with axonal transport preceded by induction of the enzyme in noradrenergic cell bodies, whereas “delayed activation” might account for the transient effect seen in dopaminergic cell body regions.
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