Stephen Meader
University of Oxford
15 Papers
59 Citations
Stephen Meader is an academic researcher from University of Oxford. The author has contributed to research in topics: Genome & Biology. The author has an hindex of 13, co-authored 14 publications.
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Papers
Insights into hominid evolution from the gorilla genome sequence
Aylwyn Scally,Julien Y. Dutheil,LaDeana W. Hillier,Gregory E. Jordan,Ian Goodhead,Javier Herrero,Asger Hobolth,Tuuli Lappalainen,Thomas Mailund,Tomas Marques-Bonet,Tomas Marques-Bonet,Tomas Marques-Bonet,Shane A. McCarthy,Stephen H. Montgomery,Petra C. Schwalie,Y. Amy Tang,Michelle C Ward,Yali Xue,Bryndis Yngvadottir,Can Alkan,Lars Nørvang Andersen,Qasim Ayub,Edward V. Ball,Kathryn Beal,Brenda J. Bradley,Brenda J. Bradley,Yuan Chen,Chris Clee,Stephen Fitzgerald,Tina Graves,Yong Gu,Paul Heath,Andreas Heger,Emre Karakoc,Anja Kolb-Kokocinski,Gavin K. Laird,Gerton Lunter,Stephen Meader,Matthew Mort,James C. Mullikin,Kasper Munch,Timothy D. O’Connor,Andrew David Phillips,Javier Prado-Martinez,Anthony Rogers,Saba Sajjadian,Dominic Schmidt,Katy Shaw,Jared T. Simpson,Peter D. Stenson,Daniel J. Turner,Linda Vigilant,Albert J. Vilella,Weldon Whitener,Baoli Zhu,David Neil Cooper,Pieter J. de Jong,Emmanouil T. Dermitzakis,Evan E. Eichler,Paul Flicek,Nick Goldman,Nicholas I. Mundy,Zemin Ning,Duncan T. Odom,Duncan T. Odom,Chris P. Ponting,Michael A. Quail,Oliver A. Ryder,Stephen M. J. Searle,Wesley C. Warren,Richard K. Wilson,Mikkel H. Schierup,Jane Rogers,Chris Tyler-Smith,Richard Durbin +74 more
TL;DR: A comparison of protein coding genes reveals approximately 500 genes showing accelerated evolution on each of the gorilla, human and chimpanzee lineages, and evidence for parallel acceleration, particularly of genes involved in hearing.
Comparative and demographic analysis of orang-utan genomes.
Devin P. Locke,LaDeana W. Hillier,Wesley C. Warren,Kim C. Worley,Lynne V. Nazareth,Donna M. Muzny,Shiaw-Pyng Yang,Zhengyuan Wang,Asif T. Chinwalla,Patrick Minx,Makedonka Mitreva,Lisa Cook,Kim D. Delehaunty,Catrina Fronick,Heather Schmidt,Lucinda Fulton,Robert S. Fulton,Joanne O. Nelson,Vincent Magrini,Craig Pohl,Tina Graves,Chris Markovic,Andy Cree,Huyen Dinh,Jennifer Hume,Christie Kovar,Gerald R. Fowler,Gerton Lunter,Gerton Lunter,Stephen Meader,Andreas Heger,Chris P. Ponting,Tomas Marques-Bonet,Tomas Marques-Bonet,Can Alkan,Lin Chen,Ze Cheng,Jeffrey M. Kidd,Evan E. Eichler,Evan E. Eichler,Simon D. M. White,Stephen M. J. Searle,Albert J. Vilella,Yuan Chen,Paul Flicek,Jian Ma,Jian Ma,Brian J. Raney,Bernard B. Suh,Richard Burhans,Javier Herrero,David Haussler,Rui Faria,Rui Faria,Olga Fernando,Olga Fernando,Fleur Darré,Domènec Farré,Elodie Gazave,Meritxell Oliva,Arcadi Navarro,Roberta Roberto,Oronzo Capozzi,Nicoletta Archidiacono,Giuliano Della Valle,Stefania Purgato,Mariano Rocchi,Miriam K. Konkel,Jerilyn A. Walker,Brygg Ullmer,Mark A. Batzer,Arian F.A. Smit,Robert Hubley,Claudio Casola,Daniel R. Schrider,Matthew W. Hahn,Víctor Quesada,Xose S. Puente,Gonzalo R. Ordóñez,Carlos López-Otín,Tomas Vinar,Brona Brejova,Aakrosh Ratan,Robert S. Harris,Webb Miller,Carolin Kosiol,Heather A. Lawson,Vikas Taliwal,André L. Martins,Adam Siepel,Arindam RoyChoudhury,Xin Ma,Jeremiah D. Degenhardt,Carlos Bustamante,Ryan N. Gutenkunst,Thomas Mailund,Julien Y. Dutheil,Asger Hobolth,Mikkel H. Schierup,Oliver A. Ryder,Yuko Yoshinaga,Pieter J. de Jong,George M. Weinstock,Jeffrey Rogers,Elaine R. Mardis,Richard A. Gibbs,Richard K. Wilson +106 more
TL;DR: The orang-utan species, Pongo abelii and Pongo pygmaeus, are the most phylogenetically distant great apes from humans, thereby providing an informative perspective on hominid evolution and a primate polymorphic neocentromere, found in both Pongo species are described.
The bonobo genome compared with the chimpanzee and human genomes
Kay Prüfer,Kasper Munch,Ines Hellmann,Keiko Akagi,Jason R. Miller,Brian P. Walenz,Sergey Koren,Granger G. Sutton,Chinnappa D. Kodira,Roger Winer,James R. Knight,James C. Mullikin,Stephen Meader,Chris P. Ponting,Gerton Lunter,Saneyuki Higashino,Asger Hobolth,Julien Y. Dutheil,Emre Karakoc,Can Alkan,Can Alkan,Saba Sajjadian,Claudia Rita Catacchio,Mario Ventura,Mario Ventura,Tomas Marques-Bonet,Tomas Marques-Bonet,Evan E. Eichler,Claudine André,Rebeca Atencia,Lawrence Mugisha,Jörg Junhold,Nick Patterson,Michael Siebauer,Jeffrey M. Good,Anne Fischer,Susan E. Ptak,Michael Lachmann,David E. Symer,Thomas Mailund,Mikkel H. Schierup,Aida M. Andrés,Janet Kelso,Svante Pääbo +43 more
TL;DR: The sequencing and assembly of the bonobo genome is reported to study its evolutionary relationship with the chimpanzee and human genomes, and it is found that more than three per cent of the human genome is more closely related to either theBonobo or the chimpanzees genome than these are to each other.
571
Clinical significance of de novo and inherited copy-number variation.
A.T. van Silfhout,Jayne Y. Hehir-Kwa,B W M van Bon,Janneke H M Schuurs-Hoeijmakers,Stephen Meader,C.J. Hellebrekers,I.J. Thoonen,A.P.M. de Brouwer,Han G. Brunner,Caleb Webber,R. Pfundt,N. de Leeuw,L.B.A. de Vries +12 more
TL;DR: Patients with multiple CNVs presented with a more severe phenotype than patients with a single CNV, pointing to a combinatorial effect of the additional CNVs, and 20 de novo single‐gene CNVs that directly indicate novel genes for ID/MCA are identified.
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Two Antarctic penguin genomes reveal insights into their evolutionary history and molecular changes related to the Antarctic environment
Cai Li,Yong Zhang,Jianwen Li,Lesheng Kong,Haofu Hu,Hailin Pan,Luohao Xu,Yuan Deng,Qiye Li,Lijun Jin,Hao Yu,Yan Chen,Binghang Liu,Linfeng Yang,Shiping Liu,Yan Zhang,Yongshan Lang,Jinquan Xia,Weiming He,Qiong Shi,Sankar Subramanian,Craig D. Millar,Stephen Meader,Chris M Rands,Matthew K. Fujita,Matthew K. Fujita,Matthew J. Greenwold,Todd A. Castoe,Todd A. Castoe,David D. Pollock,Wanjun Gu,Kiwoong Nam,Kiwoong Nam,Hans Ellegren,Simon Y. W. Ho,David W. Burt,Chris P. Ponting,Erich D. Jarvis,M. Thomas P. Gilbert,M. Thomas P. Gilbert,Huanming Yang,Jian Wang,David M. Lambert,Jun Wang,Guojie Zhang +44 more
TL;DR: Analysis of effective population sizes reveals that the two penguin species experienced population expansions from ~1 million years ago to ~100 thousand years ago, but responded differently to the climatic cooling of the last glacial period.