Stephen M. Becker
University of Virginia
10 Papers
167 Citations
Stephen M. Becker is an academic researcher from University of Virginia. The author has contributed to research in topics: TaqMan & Entamoeba histolytica. The author has an hindex of 7, co-authored 10 publications.
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Papers
Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study
Jie Liu,James A Platts-Mills,Jane Juma,Furqan Kabir,Joseph Nkeze,Catherine Okoi,Darwin J. Operario,Jashim Uddin,Shahnawaz Ahmed,Pedro L. Alonso,Martin Antonio,Stephen M. Becker,William C. Blackwelder,Robert F. Breiman,Abu Syed Golam Faruque,Barry S. Fields,Jean Gratz,Rashidul Haque,Anowar Hossain,M. Jahangir Hossain,Sheikh Jarju,Farah Naz Qamar,Najeeha Talat Iqbal,Brenda Kwambana,Inacio Mandomando,Timothy L. McMurry,Caroline Ochieng,John B. Ochieng,Melvin Ochieng,Clayton Onyango,Sandra Panchalingam,Adil Kalam,Fatima Aziz,Shahida Qureshi,Thandavarayan Ramamurthy,James H Roberts,Debasish Saha,Samba O. Sow,Suzanne Stroup,Dipika Sur,Boubou Tamboura,Mami Taniuchi,Sharon M. Tennant,Deanna Toema,Yukun Wu,Anita K. M. Zaidi,James P. Nataro,Karen L. Kotloff,Myron M. Levine,Eric R. Houpt +49 more
TL;DR: A quantitative molecular diagnostic approach improved population-level and case-level characterisation of the causes of diarrhoea and indicated a high burden of disease associated with six pathogens, for which targeted treatment should be prioritised.
759
A Laboratory-Developed TaqMan Array Card for Simultaneous Detection of 19 Enteropathogens
Jie Liu,Jean Gratz,Caroline Amour,Gibson S. Kibiki,Stephen M. Becker,Lalitha Janaki,Jaco J. Verweij,Mami Taniuchi,Shihab U. Sobuz,Rashidul Haque,Doris M. Haverstick,Eric R. Houpt +11 more
TL;DR: An enteric TaqMan Array Card to detect 19 enteropathogens, including viruses (adenovirus, astrovirus, norovirus GII, rotavirus, and sapovirus), bacteria (Campylobacter jejuni/C. difficile, Salmonella, Vibrio cholerae, diarrheagenic Escherichia coli, and Entamoeba histolytica), and helminths is developed.
384
Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica
Xiaoti Guo,Margo R. Roberts,Stephen M. Becker,Bradley S. Podd,Yiying Zhang,Streamson C. Chua,Martin G. Myers,Priya Duggal,Eric R. Houpt,William A. Petri +9 more
TL;DR: It is concluded that leptin-mediated resistance to amebiasis is via its actions on intestinal epithelium rather than hematopoietic cells or the brain, and requires leptin receptor signaling through both the STAT3 and SHP2/ERK pathways.
117
Epithelial Cell Apoptosis Facilitates Entamoeba histolytica Infection in the Gut
Stephen M. Becker,Kyou-Nam Cho,Xiaoti Guo,Kirsten Fendig,Mohammed N. Oosman,Robert H. Whitehead,Steven M. Cohn,Eric R. Houpt +7 more
TL;DR: It is concluded that epithelial cell apoptosis in the intestine facilitates amebic infection in this mouse model of intestinal amebiasis and the parasite's strategy for inducing apoptosis may point to key virulence factors, and therapeutic maneuvers to diminish epithelial apoptosis might be useful in amEBic colitis.
42
Efficacy of antiamebic drugs in a mouse model.
TL;DR: Examination of drug efficacy in both in vitro and in vivo models of intestinal amebiasis showed metronidazole remained the most effective in vivo, both in preventative and curative regimens, underscoring the value of animal models in evaluating future therapies.