Metyrapone is a competitive inhibitor of 11β-hydroxysteroid dehydrogenase type 1 reductase

Hormonal control of lung maturation

Discordant accelerated pulmonary maturation after adrenocorticotropic hormone-induced labor in twin sheep fetuses.

Summary. Previous studies have demonstrated a role for the beta-adrenergic system in the maturation of the fetal alveolar epithelium. Chronic blockade of beta-adrenergic binding sites has been shown to adversely eff e c t p hysiologic and biochemical indices of fetal lung maturation. In the present study timed-pregnant female Sprague-Dawley rats were treated with a continuous 0.5 mg/hr dose of propranolol HCl, or saline, via an osmotic pump. The treatment periods were days 18-21, or 20-23 of gestation. Fetal body weights were obtained, and the morphology of the fetal lungs studied by light and electron microscopy. Cytoplasmic volume densities of lamellar inclusion bodies and glycogen within d eveloping type II alveolar epithelial cells were also determined. In addition, total phospholipids (as phosphorus) and glycogen content were determined b i o c h e m i c a l l y . The fetuses from females treated from day 20-23 demonstrated no differences between salinetreated and propranolol-treated groups, in either fetal weight or the morphologic appearance of the developing lung. In contrast, the fetuses from mothers treated from day 18-21 with propranolol were significantly smaller, and their lungs appeared less mature than saline-treated counterparts. The glycogen content of developing type II alveolar epithelial cells was significantly more abundant (as judged by stereologic and biochemical analyses) in the propranolol-treated fetuses. In addition, total phospholipids were decreased in the propranolol-treated 21-day fetuses. The results of the present study suggest that the development of the alveolar epithelium is s e n s i t i ve to continuous beta-adrenergic blockade by propranolol during a critical time late in gestation.

/pdf/time-dependent-effects-of-maternal-continuous-propranolol-on-2xgq06sfql.pdf

Time-dependent effects of maternal continuous propranolol on fetal lung development in rats.

Propranolol inhibits the maturational effect of adrenocorticotropin in the fetal sheep lung.

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Propranolol inhibits the maturational effect of adrenocorticotropin in the fetal sheep lung.