Stephen L. Holtz
Janelia Farm Research Campus
5 Papers
Stephen L. Holtz is an academic researcher from Janelia Farm Research Campus. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 1, co-authored 1 publications.
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Papers
Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly
Hongjie Li,Jasper Janssens,Maxime de Waegeneer,Sai Saroja Kolluru,Kristofer Davie,Vincent Gardeux,Wouter Saelens,Fabrice P. A. David,Maria Brbic,Katina I. Spanier,Jure Leskovec,Colleen N. McLaughlin,Qijing Xie,Robert C. Jones,Katja Brueckner,Jiwon Shim,Sudhir Gopal Tattikota,Frank Schnorrer,Katja Rust,Todd G. Nystul,Zita Carvalho-Santos,Carlos Ribeiro,Soumitra Pal,Sharvani Mahadevaraju,Teresa M. Przytycka,Aaron M. Allen,Stephen F. Goodwin,Cameron Wynn Berry,Margaret T. Fuller,Helen White-Cooper,Erika Matunis,Stephen DiNardo,Anthony Galenza,Lucy Erin O'Brien,Julian A. T. Dow,Heinrich Jasper,Brian Oliver,Norbert Perrimon,Bart Deplancke,Stephen R. Quake,Liqun Luo,Stein Aerts,Devika Agarwal,Yasir H. Ahmed-Braimah,Michelle N. Arbeitman,Majd M. Ariss,Jordan Augsburger,K. R. Ayush,Catherine C. Baker,Torsten U. Banisch,Katja Birker,Rolf Bodmer,Benjamin Bolival,Susanna E. Brantley,Julie A. Brill,Nora C Brown,Norene A. Buehner,Xiao Cai,Rita Cardoso-Figueiredo,Fernando Casares,Amy K. Chang,Thomas R. Clandinin,Sheela Crasta,Claude Desplan,Angela M. Detweiler,Darshan B. Dhakan,Erika Donà,Steffi Engert,Swann Floc'hlay,Nancy George,Amanda J. González-Segarra,Andrew K. Groves,Samantha C. Gumbin,Yanmeng Guo,Devon E Harris,Yael Heifetz,Stephen L. Holtz,Felix Horns,Bruno Hudry,Ruei-Jiun Hung,Yuh Nung Jan,Jacob S Jaszczak,Gregory S.X.E. Jefferis,Jim Karkanias,Timothy L. Karr,Nadja Sandra Katheder,James N. Kezos,Anna Kim,Seung K. Kim,Lutz Kockel,Nikolaos Konstantinides,Thomas B. Kornberg,Henry M. Krause,Andrew T. Labott,Meghan Laturney,Ruth Lehmann,Sarah G Leinwand,Jiefu Li,Joshua Shing Shun Li,Kai Li,Kexin Li,Liying Li,Tun Li,Maria Litovchenko,Hanji Liu,Yifang Liu,Tzu-Chiao Lu,Jonathan Manning,A. De Mase,Mikaela Matera-Vatnick,Neuza Reis Matias,Caitlin E. McDonough-Goldstein,Aaron McGeever,Alex D McLachlan,Paola Moreno-Román,Norma F. Neff,Megan Neville,Sang Ngo,Tanja Nielsen,Caitlin E. O’Brien,David Osumi-Sutherland,Mehmet Neset Özel,Irene Papatheodorou,Maja Petkovic,Ch. Pilgrim,Angela Oliveira Pisco,Carolina E. Reisenman,Erin Sanders,Gilberto dos Santos,Kristin Scott,Aparna Sherlekar,Philip Shiu,David Sims,Rene Sit,Maija Slaidina,Harold E. Smith,Gabriella R Sterne,Yun-Han Su,Daniel Alexander Sutton,Marco Tamayo,Michelle Tan,Ibrahim Tastekin,Christoph Daniel Treiber,David Vacek,Georg Vogler,Scott Waddell,Wanpeng Wang,Rachel Wilson,Mariana F. Wolfner,Yiu-Cheung E. Wong,Anthony Xie,Jun Xu,Shinya Yamamoto,Jiamei Yan,Zepeng Yao,Kazuki Yoda,Ruijun Zhu,Robert P. Zinzen +157 more
TL;DR: A single-cell atlas of the adult fly, Tabula Drosophilae, that includes 580,000 nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to >250 distinct cell types is presented, providing an in-depth analysis of cell type–related gene signatures and transcription factor markers, as as sexual dimorphism, across the whole animal.
Contributions of the 12 neuron classes in the fly lamina to motion vision.
TL;DR: This work constructed specific genetic driver lines for each of the 12 neuron classes in the lamina and depolarized and hyperpolarized each neuron type and quantified fly behavioral responses to a diverse set of motion stimuli.
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A cell type in the visual system that receives feedback about limb movement
Alexandra K. Hartman,Matthew F. Collie,Emily Kellogg,Stephen L. Holtz +3 more
Functional specializations of Drosophila primary mechanosensory neurons.
Stephen L. Holtz,Rachel Wilson +1 more
TL;DR: In this paper , the authors studied how forces activate primary mechanosensors, and how neurons encode detailed features of mechanical stimuli, and found that it is difficult to record activity from identifiable mechano-sensors in situ while delivering controlled stimuli.
Specialized parallel pathways for adaptive control of visual object pursuit
Matthew F. Collie,Chennan Jin,Emily Kellogg,Quinn X. Vanderbeck,Alexandra K. Hartman,Stephen L. Holtz,Rachel I. Wilson +6 more
TL;DR: Adaptive control in Drosophila pursuit involves two parallel pathways: one for peripheral object detection and steering, and another for central object detection and steering, with flexible gain and recruitment based on arousal and velocity.