Stephen J. Ohms
Australian National University
23 Papers
78 Citations
Stephen J. Ohms is an academic researcher from Australian National University. The author has contributed to research in topics: Gene expression profiling & microRNA. The author has an hindex of 13, co-authored 23 publications. Previous affiliations of Stephen J. Ohms include Monash University, Clayton campus & University of Auckland.
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Papers
Identification of active site residues of the pro-metastatic endoglycosidase heparanase
Mark D. Hulett,June R. Hornby,Stephen J. Ohms,Johannes Zuegg,Craig Freeman,Jill E. Gready,Christopher R. Parish +6 more
TL;DR: Analysis of sequence alignments and secondary structure predictions suggest that heparanase is a member of the clan A glycosyl hydrolases and has a common catalytic mechanism that involves two conserved acidic residues, a putative proton donor at Glu(225) and a nucleophile at GLU(343).
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An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours
TL;DR: The utility of the MM model for determining extravascular transport parameters is demonstrated, and it is indicated that much of the impediment to diffusion of basic DNA intercalators in tumour tissue may arise from lysosomal sequestration rather than DNA binding.
95
Changes in the expression of miR-381 and miR-495 are inversely associated with the expression of the MDR1 gene and development of multi-drug resistance.
Yan Xu,Yan Xu,Yan Xu,Stephen J. Ohms,Zhen Li,Qiao Wang,Guangming Gong,Yiqiao Hu,Zhiyong Mao,M. Frances Shannon,M. Frances Shannon,Jun Y. Fan +11 more
TL;DR: It is demonstrated that changing the levels of certain miR species modulates the MDR phenotype in leukemia cells, and proposed is further exploration of the use of miR-based therapies to overcome MDR.
Plasticity of DNA methylation in mouse T cell activation and differentiation
Yan Li,Yan Li,Guobing Chen,Lina Ma,Stephen J. Ohms,Chao Sun,M. Frances Shannon,M. Frances Shannon,Jun Y. Fan +8 more
TL;DR: It is demonstrated that DNA methylation is dynamic and flexible in CD4+ T cells and changes rapidly both in a genome-wide and in a targeted manner during T cell activation, differentiation and aging.
Activation of LINE-1 Retrotransposon Increases the Risk of Epithelial-Mesenchymal Transition and Metastasis in Epithelial Cancer.
Danny Rangasamy,Nibedita Lenka,Stephen J. Ohms,Jane E. Dahlstrom,Anneke C. Blackburn,Philip G. Board +5 more
TL;DR: How expression of the normally repressed LINE-1 (or L1) retrotransposons activates the process of EMT and the development of metastases is discussed and an overview of L1 activity in cancer cells is presented including how genes involved in proliferation, invasive and metastasis are modulated by L1 expression.