Stephen H. Settle
Vanderbilt University
8 Papers
41 Citations
Stephen H. Settle is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Biology & Regulation of gene expression. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Stephen H. Settle include United States Department of Veterans Affairs.
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Papers
Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
Sergio Kaiser,Young-Kyu Park,Jeffrey L. Franklin,Richard B. Halberg,Ming Yu,Walter J. Jessen,Johannes M. Freudenberg,Xiaodi Chen,Kevin M. Haigis,Anil G. Jegga,Sue Kong,Bhuvaneswari Sakthivel,Huan Xu,Timothy Reichling,Mohammad Azhar,Gregory P. Boivin,Reade B. Roberts,Anika C. Bissahoyo,Fausto Gonzales,Greg Bloom,Steven A. Eschrich,Scott L. Carter,Jeremy Aronow,John Kleimeyer,Michael Kleimeyer,Vivek Ramaswamy,Stephen H. Settle,Braden Boone,Shawn Levy,Jonathan M. Graff,Thomas Doetschman,Joanna Groden,William F. Dove,David W. Threadgill,Timothy J. Yeatman,Robert J. Coffey,Bruce J. Aronow +36 more
TL;DR: Cross-species, developmental, and multi-model gene expression patterning comparisons provide an integrated and versatile framework for definition of transcriptional programs associated with oncogenesis and provide a general method for identifying pattern-specific biomarkers and therapeutic targets.
Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis
Reade B. Roberts,Lu Min,M. Kay Washington,Sandra J. Olsen,Stephen H. Settle,Robert J. Coffey,Robert J. Coffey,David W. Threadgill,David W. Threadgill +8 more
TL;DR: It is suggested that normal Egfr activity is required for establishment of intestinal tumors in the ApcMin model between initiation and subsequent expansion of initiated tumors, suggesting that Egfr inhibitors may be useful for advanced colorectal cancer treatment.
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The silver gene of Drosophila melanogaster encodes multiple carboxypeptidases similar to mammalian prohormone-processing enzymes.
TL;DR: The identified and cloned the DNA encoding the svr gene and the sequence of several partially overlapping cDNAs derived from svr mRNAs indicates that the silver proteins are members of the family of preprotein-processing carboxypeptidases that includes the human carboxypes E, M, and N.
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Chronic treatment of Ménétrier's disease with erbitux: Clinical efficacy and insight into pathophysiology
Stephen H. Settle,Kay Washington,Christopher D. Lind,Scott Itzkowitz,W. Haley Fiske,J.Steven Burdick,W. Gray Jerome,Margaret Ray,Wilfred M. Weinstein,Robert J. Coffey,Robert J. Coffey +10 more
TL;DR: The efficacy of prolonged Erbitux therapy in patients with different presentations of severe Ménétrier's disease is demonstrated and insight is provided into the pathophysiology of the protein-losing gastropathy.
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Gene expression profile analysis of mouse colon embryonic development.
Young-Kyu Park,Jeffrey L. Franklin,Stephen H. Settle,Shawn Levy,Eunkyung Chung,Loice H. Jeyakumar,Yu Shyr,Mary Kay Washington,Robert H. Whitehead,Bruce J. Aronow,Robert J. Coffey,Robert J. Coffey +11 more
TL;DR: A molecular portrait of colonic development during late embryogenesis is provided and should be a valuable resource for investigators interested in Colonic development and neoplasia, as well as comparative organogenesis.
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