Stephen E. Kendall
City of Hope National Medical Center
10 Papers
63 Citations
Stephen E. Kendall is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Neural stem cell & Glioma. The author has an hindex of 10, co-authored 10 publications. Previous affiliations of Stephen E. Kendall include Beckman Research Institute.
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Papers
Urokinase plasminogen activator and urokinase plasminogen activator receptor mediate human stem cell tropism to malignant solid tumors.
Margarita Gutova,Joseph Najbauer,Richard T. Frank,Stephen E. Kendall,Anna Gevorgyan,Marianne Z. Metz,Mark Guevorkian,Marissa Edmiston,Donghong Zhao,Carlotta A. Glackin,Seung U. Kim,Seung U. Kim,Karen S. Aboody +12 more
TL;DR: It is concluded that expression of uPA and uPAR in cancer cells underlies a novel mechanism of stem cell tropism to malignant solid tumors, which may be important for development of optimal stem cell‐based therapies.
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Neural stem cell targeting of glioma is dependent on phosphoinositide 3-kinase signaling.
Stephen E. Kendall,Joseph Najbauer,Heather F. Johnston,Marianne Z. Metz,Shan Li,Shan Li,Marisa Bowers,Elizabeth Garcia,Seung U. Kim,Seung U. Kim,Michael E. Barish,Karen S. Aboody,Karen S. Aboody,Carlotta A. Glackin +13 more
TL;DR: It is shown that human NSC lines responded to multiple tumor‐derived growth factors and that hepatocyte growth factor (HGF) induced the strongest chemotactic response, and signaling pathways that regulate hNSC migration are similar to those that promote unregulated glioma invasion, suggesting shared cellular mechanisms and responses.
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The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma
Ellen J. Gunn,John T. Williams,Daniel T. Huynh,Michael J. Iannotti,Changho Han,Francis J. Barrios,Stephen E. Kendall,Carlotta A. Glackin,David A. Colby,Julia Kirshner +9 more
TL;DR: This is the first report of a natural product with anti-CSC activity in myeloma, suggesting that it has the potential to improve the survival of patients with MM by eliminating the relapse-causing MM-C SCs.
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Neural Stem Cells as a Novel Platform for Tumor-Specific Delivery of Therapeutic Antibodies
Richard T. Frank,Marissa Edmiston,Stephen E. Kendall,Joseph Najbauer,Chia-Wei Cheung,Thewodros Kassa,Marianne Z. Metz,Seung U. Kim,Seung U. Kim,Carlotta A. Glackin,Anna M. Wu,Paul J. Yazaki,Karen S. Aboody +12 more
TL;DR: It is reported, for the first time, that human NSCs can be genetically modified to secrete anti-HER2 immunoglobulin molecules, and these NSC-secreted antibodies assemble properly, possess tumor cell-binding affinity and specificity, and can effectively inhibit the proliferation of HER2-overexpressing breast cancer cells in vitro.
TWIST1 associates with NF-κB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 production.
Shan Li,Stephen E. Kendall,Raquel Raices,Raquel Raices,James Finlay,Maricela Covarrubias,Maricela Covarrubias,Zheng Liu,Gina Lowe,Yu-Huey Lin,Yu-Huey Lin,Yuan Han Teh,Yuan Han Teh,Victoria Leigh,Victoria Leigh,Simi Dhillon,Simi Dhillon,Steven D. Flanagan,Karen S. Aboody,Carlotta A. Glackin +19 more
TL;DR: It is shown that TWIST1 induces the production of interleukin 8 (IL8), which activates matrix metalloproteinases and promotes invasion of breast epithelial and cancer cells, and that the TWist1 WR domain plays a critical role in TWIST 1-induced IL8 expression through interactions with and activation of NF-κB.