Stephen Delaney
AstraZeneca
17 Papers
609 Citations
Stephen Delaney is an academic researcher from AstraZeneca. The author has contributed to research in topics: Cystic fibrosis & Cystic fibrosis transmembrane conductance regulator. The author has an hindex of 10, co-authored 15 publications. Previous affiliations of Stephen Delaney include University of Queensland.
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Papers
Targeted disruption of the Wnt2 gene results in placentation defects
Susan J. Monkley,Stephen Delaney,David J. Pennisi,Jeffrey H. Christiansen,Brandon J. Wainwright +4 more
TL;DR: The results suggest that Wnt2 is required for the proper vascularisation of the mouse placenta and the placental defects in Wnt1-deficient mice result in a reduction in birthweight and perinatal lethality.
Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations.
Stephen Delaney,Eric W.F.W. Alton,Stephen N. Smith,Dominic P. Lunn,Ray Farley,Paul K. Lovelock,Scott Thomson,David A. Hume,David Lamb,David J. Porteous,J. R. Dorin,Brandon J. Wainwright +11 more
TL;DR: These mutant mice show cystic fibrosis pathology but have a reduced risk of fatal intestinal blockage compared with ‘null’ mutants, in keeping with the reduced incidence of meconium ileus in G551D patients.
131
Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels.
Stephen Delaney,Devra P. Rich,Scott Thomson,Murray Hargrave,Paul K. Lovelock,Michael J. Welsh,Brandon J. Wainwright +6 more
TL;DR: Two novel murine variants are discovered, exon 5− and exon 11b+, which represent up to 40% of mRNA in all CFTR–expressing tissues and leaves the reading frame intact.
115
The In Vivo Effects of Milrinone on the Airways of Cystic Fibrosis Mice and Human Subjects
Stephen N. Smith,Peter G. Middleton,Sharon Chadwick,Adam Jaffe,Katy A. Bush,Sarah Rolleston,Ray Farley,Stephen Delaney,Brandon J. Wainwright,Duncan M. Geddes,Eric W.F.W. Alton +10 more
TL;DR: The use of milrinone to induce chloride secretion in CF airways in vivo does not support the use of this agent in vivo.
52
Optimised generation of iPSC-derived macrophages and dendritic cells that are functionally and transcriptionally similar to their primary counterparts.
Susan J. Monkley,Jayendra Kumar Krishnaswamy,Melker Göransson,Maryam Clausen,Johan Meuller,Kristofer Thörn,Ryan Hicks,Stephen Delaney,Louise Stjernborg +8 more
TL;DR: This study provides a detailed and accurate profile of iPSC-derived monocytic lineage cells and demonstrates a complete switch ofiPSCs to cells expressing a monocyte, macrophage or DC specific gene profile.